A stonemason with accelerated silicosis in the setting of tumour necrosis factor alpha inhibitor therapy

Timothy Baird; Michael Putt; Andrew Dettrick

doi:10.1002/rcr2.171

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A stonemason with accelerated silicosis in the setting of tumour necrosis factor alpha inhibitor therapy

Journal article

Open access

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A stonemason with accelerated silicosis in the setting of tumour necrosis factor alpha inhibitor therapy

Timothy Baird, Michael Putt and Andrew Dettrick

Respirology Case Reports, Vol.4(5), pp.1-3

2016

DOI: https://doi.org/10.1002/rcr2.171

PMCID: PMC4970307

PMID: 27516887

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Abstract

Silicosis

stonemason

TNF‐alpha inhibitor

We present the case of a 26-year-old stonemason with accelerated silicosis in the setting of treatment for psoriasis with the tumour necrosis factor alpha (TNF-alpha) inhibitor adalimumab. Accelerated silicosis is an important occupational lung disease with a poor prognosis and limited treatment options [1]. Although the exact pathogenesis remains unknown, it is suggested that secretion of cytokines, including TNF-alpha, plays a central role in disease progression [1,2]. Importantly, however, TNF-alpha inhibitors, in addition to resulting in an increased risk of infection, are also now being seen to cause interstitial lung disease [3,4]. To our knowledge, this is the first documented patient to develop silicosis whilst on TNF-alpha inhibitor therapy. This case challenges the theory behind TNF-alpha's exact role in the pathogenesis of silicosis and lung fibrosis, highlights the importance of monitoring individuals with both occupational and drug exposures, and illustrates the increasing difficulties physicians face in investigating patients with pulmonary infiltrates and multiple possible aetiologies.

Details

Title: A stonemason with accelerated silicosis in the setting of tumour necrosis factor alpha inhibitor therapy
Authors: Timothy Baird (Author) - Nambour General Hospital
Michael Putt (Author) - Nambour General Hospital
Andrew Dettrick (Author) - University of the Sunshine Coast
Publication details: Respirology Case Reports, Vol.4(5), pp.1-3
Publisher: John Wiley & Sons, Ltd
Date published: 2016
DOI: 10.1002/rcr2.171
ISSN: 2051-3380
PMID: 27516887; PMC4970307
Copyright note: © 2016 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Organisation Unit: School of Science, Technology and Engineering
Language: English
Record Identifier: 99724098802621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Respiratory System

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