A selective role for α3 subunit glycine receptors in inflammatory pain

V L Harvey; A Caley; U C Muller; Robert J Harvey; A H Dickenson

doi:10.3389/neuro.02.014.2009

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A selective role for α3 subunit glycine receptors in inflammatory pain

Journal article

Open access

Peer reviewed

A selective role for α3 subunit glycine receptors in inflammatory pain

V L Harvey, A Caley, U C Muller, Robert J Harvey and A H Dickenson

Frontiers in Molecular Neuroscience, Vol.2(14)

2009

DOI: https://doi.org/10.3389/neuro.02.014.2009

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Abstract

Neurosciences

glycine α3 subunit

prostaglandin E2 inflammation

visceral pain

arthritis

electrophysiology

GlyR α3 has previously been found to play a critical role in pain hypersensitivity following spinal PGE2 injection, complete Freund's adjuvant (CFA) and zymosan induced peripheral inflammation. In this study, although all models displayed typical phenotypic behaviours, no significant differences were observed when comparing the pain behaviours of Glra3−/− and wild-type littermates following the injection of capsaicin, carrageenan, kaolin/carrageenan or monosodium iodoacetate, models of rheumatoid and osteoarthritis, respectively. However, clear differences were observed following CFA injection (p < 0.01). No significant differences were observed in the pain behaviours of Glra3−/− and wild-type littermates following experimentally induced neuropathic pain (partial sciatic nerve ligation). Similarly, Glra3−/− and wild-type littermates displayed indistinguishable visceromotor responses to colorectal distension (a model of visceral pain) and in vivo spinal cord dorsal horn electrophysiology revealed no differences in responses to multimodal suprathreshold stimuli, intensities which equate to higher pain scores such as those reported in the clinic. These data suggest that apart from its clear role in CFA- and zymosan-induced pain sensitisation, hypersensitivity associated with other models of inflammation, neuropathy and visceral disturbances involves mechanisms other than the EP2 receptor - GlyR α3 pathway.

Details

Title: A selective role for α3 subunit glycine receptors in inflammatory pain
Authors: V L Harvey (Author) - University College London, United Kingdom
A Caley (Author) - University College London, United Kingdom
U C Muller (Author) - University of Heidelberg, Germany
Robert J Harvey (Author) - University College London, United Kingdom
A H Dickenson (Author) - University College London, United Kingdom
Publication details: Frontiers in Molecular Neuroscience, Vol.2(14)
Publisher: Frontiers Research Foundation
Date published: 2009
DOI: 10.3389/neuro.02.014.2009
ISSN: 1662-5099
Copyright note: Copyright © 2009 Harvey, Caley, Müller, Harvey and Dickenson. This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
Organisation Unit: School of Health; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99451048702621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Neurosciences

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