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A reliable synthesis of 2- and 6-amino-β-cyclodextrin and permethylated-β-cyclodextrin
Journal article   Peer reviewed

A reliable synthesis of 2- and 6-amino-β-cyclodextrin and permethylated-β-cyclodextrin

I W Muderawan, T T Ong, C L Teck, David James Young, B C Chi and S C Ng
Tetrahedron Letters, Vol.46(46), pp.7905-7907
2005
url
https://doi.org/10.1016/j.tetlet.2005.09.099View
Published Version

Abstract

Organic Chemistry Medicinal and Biomolecular Chemistry modified cyclodextrin amino β-cyclodextrin amino permethyl-β-cyclodextrin
A new, reliable method for the introduction of an amine group at positions 2 or 6 of β-cyclodextrin and permethyl-β-cyclodextrin is described. It involves selective tosylation followed by azide substitution and almost quantitative reduction with triphenylphosphine followed by hydrolysis of the phosphinimine intermediate. © 2005 Elsevier Ltd. All rights reserved.

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