A preliminary study of breast cancer diagnosis using laboratory based small angle x-ray scattering

A R Round; S J Wilkinson; C J Hall; K D Rogers; O Glatter; Tim J Wess; I O Ellis

doi:10.1088/0031-9155/50/17/017

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A preliminary study of breast cancer diagnosis using laboratory based small angle x-ray scattering

Journal article

Peer reviewed

A preliminary study of breast cancer diagnosis using laboratory based small angle x-ray scattering

A R Round, S J Wilkinson, C J Hall, K D Rogers, O Glatter, Tim J Wess and I O Ellis

Physics in Medicine and Biology, Vol.50(17), pp.4159-4168

2005

DOI: https://doi.org/10.1088/0031-9155/50/17/017

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Abstract

Breast tissue collected from tumour samples and normal tissue from bi-lateral mastectomy procedures were examined using small angle x-ray scattering. Previous work has indicated that breast tissue disease diagnosis could be performed using small angle x-ray scattering (SAXS) from a synchrotron radiation source. The technique would be more useful to health services if it could be made to work using a conventional x-ray source. Consistent and reliable differences in x-ray scatter distributions were observed between samples from normal and tumour tissue samples using the laboratory based 'SAXSess' system. Albeit from a small number of samples, a sensitivity of 100% was obtained. This result encourages us to pursue the implementation of SAXS as a laboratory based diagnosis technique. © 2005 IOP Publishing Ltd.

Details

Title: A preliminary study of breast cancer diagnosis using laboratory based small angle x-ray scattering
Authors: A R Round (Author) - Cranfield University, United Kingdom
S J Wilkinson (Author) - Cranfield University, United Kingdom
C J Hall (Author) - Daresbury Laboratories, United Kingdom
K D Rogers (Author) - Cranfield University, United Kingdom
O Glatter (Author) - University of Graz, Austria
Tim J Wess (Author) - Cardiff University, United Kingdom
I O Ellis (Author) - Nottingham City Hospital, United Kingdom
Publication details: Physics in Medicine and Biology, Vol.50(17), pp.4159-4168
Publisher: Institute of Physics Publishing Ltd.
Date published: 2005
DOI: 10.1088/0031-9155/50/17/017
ISSN: 0031-9155
Organisation Unit: Office of the Deputy Vice-Chancellor (Academic); University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99450443102621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging