A novel role for Teneurin C-terminal Associated Peptide (TCAP) in the regulation of cardiac activity in the Sydney rock oyster, Saccostrea glomerata

Tomer Abramov; Saowaros Suwansa-ard; Patricia Mirella da Silva; Tianfang Wang; Michael C Dove; Wayne O'Connor; Laura M Parker; Fraser Russell; David A Lovejoy; Scott Cummins; Abigail Elizur

doi:10.3389/fendo.2023.1020368

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A novel role for Teneurin C-terminal Associated Peptide (TCAP) in the regulation of cardiac activity in the Sydney rock oyster, Saccostrea glomerata

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A novel role for Teneurin C-terminal Associated Peptide (TCAP) in the regulation of cardiac activity in the Sydney rock oyster, Saccostrea glomerata

Tomer Abramov, Saowaros Suwansa-ard, Patricia Mirella da Silva, Tianfang Wang, Michael C Dove, Wayne O'Connor, Laura M Parker, Fraser Russell, David A Lovejoy, Scott Cummins, …

Frontiers in Endocrinology, Vol.14, pp.1-14

2023

DOI: https://doi.org/10.3389/fendo.2023.1020368

PMCID: PMC9939839

PMID: 36814576

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Abstract

teneurin

TCAP

stress

metabolism

heart

heart rate

transcriptome

oysters

Teneurin C-terminal associated peptide (TCAP) is an ancient bioactive peptide that is highly conserved in metazoans. TCAP administration reduces cellular and behavioural stress in vertebrate and urochordate models, yet despite numerous studies in higher animals, there is limited knowledge of its role in invertebrates. In particular, there are no studies on TCAP’s effects on the heart of any metazoan, which is a critical organ in the stress response. We used the Sydney rock oyster (SRO) as an invertebrate model to investigate a potential role for sroTCAP in regulating cardiac activity, including during stress. sroTCAP is localized to the neural innervation network of the SRO heart, and suggested binding with various heart proteins related to metabolism and stress, including SOD, GAPDH and metabotropic glutamate receptor. Intramuscular injection of sroTCAP (10 pmol) significantly altered the expression of heart genes that are known to regulate remodelling processes under different conditions, and modulated several gene families responsible for stress mitigation. sroTCAP (1 and 10 pmol) was shown to cause transient bradycardia (heart rate was reduced by up to 63% and for up to 40 min post-administration), indicative of an unstressed state. In summary, this study has established a role for a TCAP in the regulation of cardiac activity through modulation of physiological and molecular components associated with energy conservation, stress and adaptation. This represents a novel function for TCAP and may have implications for higher-order metazoans.

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Title: A novel role for Teneurin C-terminal Associated Peptide (TCAP) in the regulation of cardiac activity in the Sydney rock oyster, Saccostrea glomerata
Authors: Tomer Abramov (Author) - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Saowaros Suwansa-ard (Author) - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Patricia Mirella da Silva (Author) - Universidade Federal da Paraíba
Tianfang Wang (Author) - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Michael C Dove (Author) - New South Wales Department of Primary Industries
Wayne O'Connor (Author) - New South Wales Department of Primary Industries
Laura M Parker (Author) - UNSW Australia
Fraser Russell (Author) - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
David A Lovejoy (Author) - University of Toronto
Scott Cummins (Author) - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Abigail Elizur (Corresponding Author) - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Publication details: Frontiers in Endocrinology, Vol.14, pp.1-14
Publisher: Frontiers Research Foundation
Date published: 2023
DOI: 10.3389/fendo.2023.1020368
ISSN: 1664-2392
PMID: 36814576; PMC9939839
Copyright note: © 2023 Abramov, Suwansa-ard, da Silva, Wang, Dove, O’Connor, Parker, Russell, Lovejoy, Cummins and Elizur. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Organisation Unit: School of Health - Biomedicine; GeneCology Research Centre - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99703398302621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Endocrinology & Metabolism

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