Journal article
A novel movement disorder in related male labrador retrievers characterized by extreme generalized muscular stiffness
Journal of Veterinary Internal Medicine, Vol.25(5), pp.1089-1096
2011
Abstract
Objectives: To describe the clinical phenotype of a new motor disorder in Labrador Retrievers. Animals and Methods: Case series study. Seven young male Labrador Retrievers presented for evaluation of stiff gait. Results: All affected dogs had generalized muscular stiffness, persistent at rest and resulting in restricted joint movements. They showed a forward flexed posture, festinating gait, and bradykinesia. Signs developed between 2 and 16 months of age and tended to stabilize in adulthood. Needle electromyogram in the conscious state showed continuous motor unit activity in resting epaxial and proximal limb muscles. This activity was abolished by general anesthesia. Muscle and nerve histopathology was normal. In 2 dogs necropsied, astrocytosis was evident throughout the spinal cord gray matter, reticular formation and caudate nuclei. Decreased neuronal counts were selectively found in the spinal cord Rexed's lamina VII, but not in VIII and IX. Pedigree analysis showed that the affected dogs were from 5 related litters. Conclusions and Clinical Importance: This new hypertonicity syndrome in Labrador Retrievers is unique because of the selective distribution of the histological lesions, the lack of progression in adulthood, and its exclusive occurrence in male dogs. Pedigree analysis suggests an X-linked hereditary disease, although other modes of inheritance cannot be ruled out with certainty. We hypothesize that altered output from basal nuclei and reticular formation together with motor neuron disinhibition caused by a decreased number of spinal cord interneurons leads to the muscular stiffness. © 2011 by the American College of Veterinary Internal Medicine.
Details
- Title
- A novel movement disorder in related male labrador retrievers characterized by extreme generalized muscular stiffness
- Authors
- A E Vanhaesebrouck (Author) - University of Cambridge, United KingdomG D Shelton (Author) - University of California, United StatesL Garosi (Author) - Davies Veterinary Specialists, United KingdomT R Harcourt-Brown (Author) - University of Cambridge, United KingdomJ Couturier (Author) - Davies Veterinary Specialists, United KingdomS Behr (Author) - Davies Veterinary Specialists, United KingdomRobert J Harvey (Author) - The School of Pharmacy, United KingdomN D Jeffery (Author) - University of Cambridge, United KingdomK Matiasek (Author) - University of Munich, GermanyW F Blakemore (Author) - University of Cambridge, United KingdomN Granger (Author) - University of Cambridge, United Kingdom
- Publication details
- Journal of Veterinary Internal Medicine, Vol.25(5), pp.1089-1096
- Publisher
- Wiley-Blackwell Publishing Inc.
- Date published
- 2011
- DOI
- 10.1111/j.1939-1676.2011.0757.x
- ISSN
- 0891-6640; 0891-6640
- Copyright note
- Copyright © 2011 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99450575902621
- Output Type
- Journal article
- Research Statement
- false
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