A novel invertebrate GABAA receptor-like polypeptide Sequence and pattern of gene expression

M L Hutton; Robert J Harvey; F G P Earley; E A Barnard; M G Darlison

doi:10.1016/0014-5793(93)81773-S

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A novel invertebrate GABAA receptor-like polypeptide Sequence and pattern of gene expression

Journal article

Peer reviewed

A novel invertebrate GABAA receptor-like polypeptide Sequence and pattern of gene expression

M L Hutton, Robert J Harvey, F G P Earley, E A Barnard and M G Darlison

FEBS Letters, Vol.326(1-3), pp.112-116

1993

DOI: https://doi.org/10.1016/0014-5793(93)81773-S

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Abstract

cDNA cloning

GABAA receptor-like subunit

gene organization

invertebrate ligand-gated ion channel

lymnaea stagnalis

RNase protection

A full-length complementary DNA has been isolated, from the fresh-water mollusc Lymnaea stagnalis, that encodes a polypeptide (which we have named Ã‡) that exhibits between 30% and 40% identity to vertebrate GABAA and glycine receptor subunit sequences. The locations of seven introns have been determined in the corresponding gene and six of these occur at similar relative positions as those found in vertebrate GABAA receptor genes. RNase protection studies have revealed that the transcript for this Lymnaean polypeptide is present at highest levels in the adult nervous system but that it can also be detected in peripheral tissues. © 1993.

Details

Title: A novel invertebrate GABAA receptor-like polypeptide Sequence and pattern of gene expression
Authors: M L Hutton (Author) - MRC Centre, United Kingdom
Robert J Harvey (Author) - MRC Centre, United Kingdom
F G P Earley (Author) - Jealott's Hill Research Station, United Kingdom
E A Barnard (Author) - MRC Centre, United Kingdom
M G Darlison (Author) - MRC Centre, United Kingdom
Publication details: FEBS Letters, Vol.326(1-3), pp.112-116
Publisher: John Wiley & Sons Ltd.
Date published: 1993
DOI: 10.1016/0014-5793(93)81773-S
ISSN: 0014-5793
Organisation Unit: School of Health; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99450697702621
Output Type: Journal article

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