Journal article
A novel invertebrate GABAA receptor-like polypeptide Sequence and pattern of gene expression
FEBS Letters, Vol.326(1-3), pp.112-116
1993
Abstract
A full-length complementary DNA has been isolated, from the fresh-water mollusc Lymnaea stagnalis, that encodes a polypeptide (which we have named Ç) that exhibits between 30% and 40% identity to vertebrate GABAA and glycine receptor subunit sequences. The locations of seven introns have been determined in the corresponding gene and six of these occur at similar relative positions as those found in vertebrate GABAA receptor genes. RNase protection studies have revealed that the transcript for this Lymnaean polypeptide is present at highest levels in the adult nervous system but that it can also be detected in peripheral tissues. © 1993.
Details
- Title
- A novel invertebrate GABAA receptor-like polypeptide Sequence and pattern of gene expression
- Authors
- M L Hutton (Author) - MRC Centre, United KingdomRobert J Harvey (Author) - MRC Centre, United KingdomF G P Earley (Author) - Jealott's Hill Research Station, United KingdomE A Barnard (Author) - MRC Centre, United KingdomM G Darlison (Author) - MRC Centre, United Kingdom
- Publication details
- FEBS Letters, Vol.326(1-3), pp.112-116
- Publisher
- John Wiley & Sons Ltd.
- DOI
- 10.1016/0014-5793(93)81773-S
- ISSN
- 0014-5793
- Organisation Unit
- Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health
- Language
- English
- Record Identifier
- 99450697702621
- Output Type
- Journal article
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