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Published VersionCC BY V4.0, Open Access
Journal article
A narrative review of the epigenetics of post-traumatic stress disorder and post-traumatic stress disorder treatment
Frontiers in Psychiatry, Vol.13, pp.1-12
2022
PMID: 36419982
Abstract
Epigenetic research in post-traumatic stress disorder (PTSD) is essential, given that environmental stressors and fear play such a crucial role in its development. As such, it may provide a framework for understanding individual differences in the prevalence of the disorder and in treatment response. This paper reviews the epigenetic markers associated with PTSD and its treatment, including candidate genes and epigenome-wide studies. Because the etiopathogenesis of PTSD rests heavily on learning and memory, we also draw upon animal neuroepigenetic research on the acquisition, update and erasure of fear memory, focusing on the mechanisms associated with memory reconsolidation. Reconsolidation blockade (or impairment) treatment in PTSD has been studied in clinical trials and, from a neurological perspective, may hold promise for identifying epigenetic markers of successful therapy. We conclude this paper by discussing several key considerations and challenges in epigenetic research on PTSD in humans.
Details
- Title
- A narrative review of the epigenetics of post-traumatic stress disorder and post-traumatic stress disorder treatment
- Authors
- Lei Cao-Lei - Douglas Mental Health University InstituteDaniel Saumier - Douglas Mental Health University InstituteJustine Fortin - Université du Québec à MontréalAlain Brunet (Corresponding Author) - McGill University
- Publication details
- Frontiers in Psychiatry, Vol.13, pp.1-12
- Publisher
- Frontiers Research Foundation
- Date published
- 2022
- DOI
- 10.3389/fpsyt.2022.857087
- ISSN
- 1664-0640
- PMID
- 36419982
- Copyright note
- © 2022 Cao-Lei, Saumier, Fortin and Brunet. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Organisation Unit
- Thompson Institute
- Language
- English
- Record Identifier
- 991105839302621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Psychiatry
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