Journal article
A model of amygdala function following plastic changes at specific synapses during extinction
Neurobiology of Stress, Vol.10, 100159
2019
Appears in Thompson Institute Research Collection
Abstract
The synaptic networks in the amygdala have been the subject of intense interest in recent times, primarily because of the role of this structure in emotion. Fear and itsextinction depend on the workings of these networks, with particular interest in extinction because of its potential to ameliorate adverse symptoms associated withpost-traumatic stress disorder. Here we place emphasis on the extinction networks revealed by recent techniques, and on the probable plasticity properties of theirsynaptic connections. We use modules of neurons representing each of the principal components identified as involved in extinction. Each of these modules consistsof neural networks, containing specific ratios of excitatory and specialized inhibitory neurons as well as synaptic plasticity mechanisms appropriate for the com-ponent of the amygdala they represent. While these models can produce dynamic output, here we concentrate on the equilibrium outputs and do not model thedetails of the plasticity mechanisms. Pavlovian fear conditioning generates a fear memory in the lateral amygdala module that leads to activation of neurons in thebasal nucleus fear module but not in the basal nucleus extinction module. Extinction protocols excite infralimbic medial prefrontal cortex neurons (IL) which in turnexcite so-called extinction neurons in the amygdala, leading to the release of endocannabinoids from them and an increase in efficacy of synapses formed by lateralamygdala neurons on them. The model simulations show how such a mechanism could explain experimental observations involving the role of IL as well asendocannabinoids in different temporal phases of extinction.
Details
- Title
- A model of amygdala function following plastic changes at specific synapses during extinction
- Authors
- Maxwell Bennett (Author) - University of SydneyLes Farnell (Author) - University of SydneyWilliam G Gibson (Author) - University of SydneyJim Lagopoulos (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
- Publication details
- Neurobiology of Stress, Vol.10, 100159
- Publisher
- Elsevier BV
- Date published
- 2019
- DOI
- 10.1016/j.ynstr.2019.100159
- ISSN
- 2352-2895; 2352-2895
- Copyright note
- Copyright © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99450902902621
- Output Type
- Journal article
- Research Statement
- false
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