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Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
A meta-analysis on the role of pre-existing chronic disease in the cardiac complications of SARS-CoV-2 infection
iScience, Vol.24(4), pp.1-33
2021
Appears in COVID-19 Research
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with multiple direct and indirect cardiovascular complications. We sought to analyze the association of host co-morbidities (chronic respiratory illnesses, cardiovascular disease [CVD], hypertension or diabetes mellitus [DM]) with the acute cardiovascular complications associated with SARS-CoV-2 infection. Individual analyses of the majority of studies found median age was higher by ~10 years in patients with cardiovascular complications. Pooled analyses showed development of SARS-CoV-2 cardiovascular complications was significantly increased in patients with chronic respiratory illness (odds ratio (OR): 1.67 [1.48, 1.88]), CVD (OR: 3.37 [2.57, 4.43]), hypertension (OR: 2.68 [2.11, 3.41]), DM (OR: 1.60 [1.31, 1.95]) and male sex (OR: 1.31 [1.21, 1.42]), findings that were mostly conserved during sub-analysis of studies stratified into global geographic regions. Age, chronic respiratory illness, CVD, hypertension, DM, and male sex may represent prognostic factors for the development of cardiovascular complications in COVID-19 disease, highlighting the need for a multidisciplinary approach to chronic disease patient management.
Details
- Title
- A meta-analysis on the role of pre-existing chronic disease in the cardiac complications of SARS-CoV-2 infection
- Authors
- Jane E Sinclair (Author) - School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, AustraliaYanshan Zhu (Author) - The University of QueenslandGang Xu (Author) - Guangzhou First People's HospitalWei Ma (Author) - South China University of TechnologyHaiyan Shi (Author) - Guangzhou Eighth People's HospitalKun-Long Ma (Author) - Chongqing Medical UniversityChun-Feng Cao (Author) - Chongqing Medical UniversityLing-Xi Kong (Author) - Yongchuan Hospital of Chongqing Medical University, Yongchuan, Chongqing, ChinaKe-Qiang Wan (Author) - Chongqing Medical UniversityJuan Liao (Author) - Chongqing Medical UniversityHai-Qiang Wang (Author) - Shaanxi University of Chinese MedicineMatt Arentz (Author) - University of WashingtonMeredith A Redd (Author) - The University of QueenslandLinda A Gallo (Author) - The University of QueenslandKirsty R Short (Author) - School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
- Publication details
- iScience, Vol.24(4), pp.1-33
- Publisher
- Cell Press
- Date published
- 2021
- DOI
- 10.1016/j.isci.2021.102264
- ISSN
- 2589-0042
- Copyright note
- Copyright 2021 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99620308402621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Cardiac & Cardiovascular Systems
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Source: InCites