A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

A A Al Olama; Z Kote-Jarai; F R Schumacher; F Wiklund; S I Berndt; S Benlloch; G G Giles; G Severi; D E Neal; F C Hamdy; Jenny L Donovan; D J Hunter; B E Henderson; M J Thun; M Gaziano; E L Giovannucci; A Siddiq; R C Travis; D G Cox; F Canzian; E Riboli; T J Key; G Andriole; D Albanes; R B Hayes; J Schleutker; A Auvinen; T L J Tammela; M Weischer; J L Stanford; E A Ostrander; C Cybulski; J Lubinski; S N Thibodeau; D J Schaid; K D Sorensen; J Batra; J A Clements; S Chambers; J Aitken; R A Gardiner; C Maier; W Vogel; T Dörk; H Brenner; T Habuchi; S Ingles; E M John; J L Dickinson; L Cannon-Albright; M R Teixeira; R Kaneva; H W Zhang; Y J Lu; J Y Park; K A Cooney; K R Muir; D A Leongamornlert; E Saunders; M Tymrakiewicz; N Mahmud; M Guy; K Govindasami; L T O'Brien; R A Wilkinson; A L Hall; E J Sawyer; T Dadaev; J Morrison; D P Dearnaley; A Horwich; R A Huddart; V S Khoo; C C Parker; N Van As; C J Woodhouse; A Thompson; T Dudderidge; C Ogden; C S Cooper; A Lophatonanon; M C Southey; J L Hopper; D English; J Virtamo; L L Marchand; D Campa; R Kaaks; S Lindstrom; W R Diver; S Gapstur; M Yeager; A Cox; M C Stern; R Corral; M Aly; W Isaacs; J Adolfsson; J Xu; S L Zheng; T Wahlfors; K Taari; P Kujala; P Klarskov; B G Nordestgaard; M A Røder; R Frikke-Schmidt; S E Bojesen; L M FitzGerald; S Kolb; E M Kwon; D M Karyadi; T F Orntoft; M Borre; A Rinckleb; M Luedeke; K Herkommer; A Meyer; J Serth; J R Marthick; B Patterson; D Wokolorczyk; A Spurdle; Felicity Lose; S K McDonnell; A D Joshi; A Shahabi; P Pinto; J Santos; A Ray; T A Sellers; H Y Lin; R A Stephenson; C Teerlink; H Muller; D Rothenbacher; N Tsuchiya; S Narita; G W Cao; C Slavov; V Mitev; S Chanock; H Gronberg; C A Haiman; P Kraft; D F Easton; R A Eeles

doi:10.1093/hmg/dds425

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A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

Journal article

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A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

A A Al Olama, Z Kote-Jarai, F R Schumacher, F Wiklund, S I Berndt, S Benlloch, G G Giles, G Severi, D E Neal, F C Hamdy, …

Human Molecular Genetics, Vol.22(2), pp.408-415

2013

DOI: https://doi.org/10.1093/hmg/dds425

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Abstract

Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significantSNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 × 10-8]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis. © The Author 2012. Published by Oxford University Press. All rights reserved.

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Title: A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease
Authors: A A Al Olama (Author)
Z Kote-Jarai (Author)
F R Schumacher (Author)
F Wiklund (Author)
S I Berndt (Author)
S Benlloch (Author)
G G Giles (Author)
G Severi (Author)
D E Neal (Author)
F C Hamdy (Author)
Jenny L Donovan (Author)
D J Hunter (Author)
B E Henderson (Author)
M J Thun (Author)
M Gaziano (Author)
E L Giovannucci (Author)
A Siddiq (Author)
R C Travis (Author)
D G Cox (Author)
F Canzian (Author)
E Riboli (Author)
T J Key (Author)
G Andriole (Author)
D Albanes (Author)
R B Hayes (Author)
J Schleutker (Author)
A Auvinen (Author)
T L J Tammela (Author)
M Weischer (Author)
J L Stanford (Author)
E A Ostrander (Author)
C Cybulski (Author)
J Lubinski (Author)
S N Thibodeau (Author)
D J Schaid (Author)
K D Sorensen (Author)
J Batra (Author)
J A Clements (Author)
S Chambers (Author)
J Aitken (Author)
R A Gardiner (Author)
C Maier (Author)
W Vogel (Author)
T Dörk (Author)
H Brenner (Author)
T Habuchi (Author)
S Ingles (Author)
E M John (Author)
J L Dickinson (Author)
L Cannon-Albright (Author)
M R Teixeira (Author)
R Kaneva (Author)
H W Zhang (Author)
Y J Lu (Author)
J Y Park (Author)
K A Cooney (Author)
K R Muir (Author)
D A Leongamornlert (Author)
E Saunders (Author)
M Tymrakiewicz (Author)
N Mahmud (Author)
M Guy (Author)
K Govindasami (Author)
L T O'Brien (Author)
R A Wilkinson (Author)
A L Hall (Author)
E J Sawyer (Author)
T Dadaev (Author)
J Morrison (Author)
D P Dearnaley (Author)
A Horwich (Author)
R A Huddart (Author)
V S Khoo (Author)
C C Parker (Author)
N Van As (Author)
C J Woodhouse (Author)
A Thompson (Author)
T Dudderidge (Author)
C Ogden (Author)
C S Cooper (Author)
A Lophatonanon (Author)
M C Southey (Author)
J L Hopper (Author)
D English (Author)
J Virtamo (Author)
L L Marchand (Author)
D Campa (Author)
R Kaaks (Author)
S Lindstrom (Author)
W R Diver (Author)
S Gapstur (Author)
M Yeager (Author)
A Cox (Author)
M C Stern (Author)
R Corral (Author)
M Aly (Author)
W Isaacs (Author)
J Adolfsson (Author)
J Xu (Author)
S L Zheng (Author)
T Wahlfors (Author)
K Taari (Author)
P Kujala (Author)
P Klarskov (Author)
B G Nordestgaard (Author)
M A Røder (Author)
R Frikke-Schmidt (Author)
S E Bojesen (Author)
L M FitzGerald (Author)
S Kolb (Author)
E M Kwon (Author)
D M Karyadi (Author)
T F Orntoft (Author)
M Borre (Author)
A Rinckleb (Author)
M Luedeke (Author)
K Herkommer (Author)
A Meyer (Author)
J Serth (Author)
J R Marthick (Author)
B Patterson (Author)
D Wokolorczyk (Author)
A Spurdle (Author)
Felicity Lose (Author) - Queensland Institute of Medical Research
S K McDonnell (Author)
A D Joshi (Author)
A Shahabi (Author)
P Pinto (Author)
J Santos (Author)
A Ray (Author)
T A Sellers (Author)
H Y Lin (Author)
R A Stephenson (Author)
C Teerlink (Author)
H Muller (Author)
D Rothenbacher (Author)
N Tsuchiya (Author)
S Narita (Author)
G W Cao (Author)
C Slavov (Author)
V Mitev (Author)
S Chanock (Author)
H Gronberg (Author)
C A Haiman (Author)
P Kraft (Author)
D F Easton (Author)
R A Eeles (Author)
Publication details: Human Molecular Genetics, Vol.22(2), pp.408-415
Publisher: Oxford University Press
Date published: 2013
DOI: 10.1093/hmg/dds425
ISSN: 0964-6906
Organisation Unit: University of the Sunshine Coast, Queensland; Office of Research
Language: English
Record Identifier: 99450518502621
Output Type: Journal article

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