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Published VersionCC BY V4.0, Open Access
Journal article
A mass spectrometry database for the identification of marine animal saponin-related metabolites
Analytical and Bioanalytical Chemistry, Vol.416, pp.6893-6907
2024
PMID: 39387871
Appears in UniSC Supported Open Access Outputs
Abstract
Saponins encompass a diverse group of naturally occurring glycoside molecules exhibiting amphiphilic properties and a broad range of biological activities. There is a resurgence of interest in those saponins produced by marine organisms based on their potential therapeutic benefits, application in food products and most recently their potential involvement in intra- and inter-species chemical communication. The continual advancements in liquid chromatography techniques and mass spectrometry technologies have allowed for greater detection rates, as well as improved isolation and elucidation of saponins. These factors have significantly contributed to the expansion in the catalogue of known saponin structures isolated from marine invertebrates; however, there currently exists no specific chemical library resource to accelerate the discovery process. In this study, a Marine Animal Saponin Database (MASD v1.0) has been developed to serve as a valuable chemical repository for known marine saponin-related data, including chemical formula, molecular mass and biological origin of nearly 1000 secondary metabolites associated with saponins produced by marine invertebrates. We demonstrate its application with an exemplar asteroid extract (Acanthaster cf. solaris, also known as crown-of-thorns starfish; COTS), identifying saponins from the MASD v1.0 that have been previously reported from COTS, as well as 21 saponins isolated from multiple other related asteroid species. This database will help facilitate future research endeavours, aiding researchers in exploring the vast chemical diversity of saponins produced by marine organisms and providing ecological insights, and the realisation of their potential for various applications, including as pharmaceuticals.
Details
- Title
- A mass spectrometry database for the identification of marine animal saponin-related metabolites
- Authors
- Stuart J Smith (Corresponding Author) - University of the Sunshine Coast, Queensland, Centre for BioinnovationScott F Cummins - University of the Sunshine Coast, Queensland, Centre for BioinnovationCherie A Motti - Australian Institute of Marine ScienceTianfang Wang - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
- Publication details
- Analytical and Bioanalytical Chemistry, Vol.416, pp.6893-6907
- Publisher
- Springer
- Date published
- 2024
- DOI
- 10.1007/s00216-024-05586-1
- ISSN
- 1618-2650; 1618-2642
- PMID
- 39387871
- Copyright note
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- Grant note
- The authors recognise the funding provided through the AIMS Appropriation Project 003413. Stuart J. Smith gratefully acknowledges the support of the Australian Postgraduate Award scholarship.
- Organisation Unit
- School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 991066141302621
- Output Type
- Journal article
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