A comparison of the effects of a chlamydial vaccine administered during or after a C. muridarum urogenital infection of female mice

A J Carey; K A Cunningham; D Andrew; L M Hafner; Peter Timms; K W Beagley

doi:10.1016/j.vaccine.2011.07.012

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A comparison of the effects of a chlamydial vaccine administered during or after a C. muridarum urogenital infection of female mice

Journal article

Open access

Peer reviewed

A comparison of the effects of a chlamydial vaccine administered during or after a C. muridarum urogenital infection of female mice

A J Carey, K A Cunningham, D Andrew, L M Hafner, Peter Timms and K W Beagley

Vaccine, Vol.29(38), pp.6505-6513

2011

DOI: https://doi.org/10.1016/j.vaccine.2011.07.012

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Abstract

Chlamydia

pathology

timing of vaccination

Research into an efficacious Chlamydia trachomatis vaccine is ongoing, however, there has been no examination into the timing of vaccine administration to either asymptomatically or previously infected individuals. Using the female Chlamydia muridarum genital tract mouse model, we examined this aspect of vaccine development. Our results show timing of vaccination affected the production of systemic antibodies, but had minimal effects on mucosal antibody production. Vaccination during an active infection or after a resolved infection did not provide protection against re-exposure to Chlamydia, and did not exacerbate the development of pathological sequelae in infected mice. This demonstrates that vaccination may not be protective in individuals who are seropositive for an acute or previous chlamydial infection. © 2011.

Details

Title: A comparison of the effects of a chlamydial vaccine administered during or after a C. muridarum urogenital infection of female mice
Authors: A J Carey (Author) - Queensland University of Technology
K A Cunningham (Author) - Queensland University of Technology
D Andrew (Author) - Queensland University of Technology
L M Hafner (Author) - Queensland University of Technology
Peter Timms (Author) - Queensland University of Technology
K W Beagley (Author) - Queensland University of Technology
Publication details: Vaccine, Vol.29(38), pp.6505-6513
Publisher: Elsevier Ltd.
Date published: 2011
DOI: 10.1016/j.vaccine.2011.07.012
ISSN: 0264-410X
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99448779102621
Output Type: Journal article

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