Journal article
A biocompatible thermoset polymer binder for Direct Ink Writing of porous titanium scaffolds for bone tissue engineering
Materials Science and Engineering C: Materials for Biological Applications, Vol.95, pp.160-165
2019
Abstract
There is increasing demand for synthetic bone scaffolds for bone tissue engineering as they can counter issues such as potential harvesting morbidity and restrictions in donor sites which hamper autologous bone grafts and address the potential for disease transmission in the case of allografts. Due to their excellent biocompatibility, titanium scaffolds have great potential as bone graft substitutes as they mimic the structure and properties of human cancellous bone. Here we report on a new thermoset bio-polymer which can act as a binder for Direct Ink Writing (DIW) of titanium artificial bone scaffolds. We demonstrate the use of the binder to manufacture porous titanium scaffolds with evenly distributed and highly interconnected porosity ideal for orthopaedic applications. Due to their porous structure, the scaffolds exhibit an effective Young's modulus similar to human cortical bone, alleviating undesirable stress-shielding effects, and possess superior strength. The biocompatibility of the scaffolds was investigated in vitro by cell viability and proliferation assays using human bone-marrow-derived Mesenchymal stem cells (hMSCs). The hMSCs displayed well-spread morphologies, well-organized F-actin and large vinculin complexes confirming their excellent biocompatibility. The vinculin regions had significantly larger Focal Adhesion (FA) area and equivalent FA numbers compared to that of tissue culture plate controls, showing that the scaffolds support cell viability and promote attachment. In conclusion, we have demonstrated the excellent potential of the thermoset bio-polymer as a Direct Ink Writing ready binder for manufacture of porous titanium scaffolds for hard tissue engineering.
Details
- Title
- A biocompatible thermoset polymer binder for Direct Ink Writing of porous titanium scaffolds for bone tissue engineering
- Authors
- Yunhui Chen (Author) - University of QueenslandPingping Han (Author) - University of QueenslandLuigi-Jules Vandi (Author) - University of QueenslandAli Dehghan-Manshadi (Author) - University of QueenslandJarrad Humphry (Author) - University of QueenslandDamon Kent (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringIlaria Stefani (Author)Peter Lee (Author)Michael Heitzmann (Author)Justin Cooper-White (Author)Matthew S Dargusch (Author) - The University of Queensland
- Publication details
- Materials Science and Engineering C: Materials for Biological Applications, Vol.95, pp.160-165
- Publisher
- Elsevier BV
- Date published
- 2019
- DOI
- 10.1016/j.msec.2018.10.033
- ISSN
- 1873-0191
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 99450639702621
- Output Type
- Journal article
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- Materials Science, Biomaterials
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