Logo image
Back
A Study of the Effect of Anisotropic Gold Nanoparticles on Plasmonic Coupling with a Photosensitizer for Antimicrobial Film
Journal article   Peer reviewed

A Study of the Effect of Anisotropic Gold Nanoparticles on Plasmonic Coupling with a Photosensitizer for Antimicrobial Film

Francesco Rossi, Eng Huat Khoo, Xuai Du Su and Nguyen T K Thanh
ACS Applied Bio Materials, Vol.3(1), pp.315-326
2020
DOI: https://doi.org/10.1021/acsabm.9b00838
url
https://doi.org/10.1021/acsabm.9b00838View
Published Version

Abstract

plasmonic coupling anisotropy light-activated simulations antimicrobial surface non-contact sterilization
Development of antimicrobial surfaces for sterilization is much needed to avoid the spreading of drug resistant bacteria. Light can activate antimicrobial surfaces by an interaction between nanoparticles and a photosensitizer dye, to produce a steady and efficient killing of bacteria. The film studied in this work contains gold nanorods (AuNRs) of 32 nm length and 16 nm diameter and gold nanostars (AuNSs) of 50 nm of diameter, in combination with crystal violet dye (CV). The surface plasmon resonance (SPR) of the nanoparticles used in the film was mathematically simulated and characterized to understand difference SPR between the particles. Their effects on plasmonic coupling with the dye, thus the production of reactive oxygen species (ROS) and consequently the activity of the film against bacteria were studied. The films showed great antimicrobial activity against gram negative bacteria (E. coli) in 4 h of light exposure, when modified with AuNSs, it could kill E. coli in 5 orders of magnitudes (5- log) and the one modified with AuNRs could kill with 4 order of magnitudes (4-log). While maintaining partial activity against gram positive bacteria (S. aureus), i.e. being able to kill in 2.5 orders of magnitudes by the film containing AuNSs and 3 orders of magnitudes by those containing AuNRs. The differential response of gram (-) and gram (+) bacteria to the ROS generated by the films, would allow more targeted approach for specific bacterial species, for example, surfaces of bedpans or common contact surfaces (handles, handrails etc.) that are contaminated principally by gram (-) or gram (+) bacteria, respectively.

Details

Metrics

78 Record Views
16 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types
Domestic collaboration
International collaboration
Web Of Science research areas
Materials Science, Biomaterials
Nanoscience & Nanotechnology

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

Source: InCites

Logo image