Journal article
A Study of the Effect of Anisotropic Gold Nanoparticles on Plasmonic Coupling with a Photosensitizer for Antimicrobial Film
ACS Applied Bio Materials, Vol.3(1), pp.315-326
2020
Abstract
Development of antimicrobial surfaces for sterilization is much needed to avoid the spreading of drug resistant bacteria. Light can activate antimicrobial surfaces by an interaction between nanoparticles and a photosensitizer dye, to produce a steady and efficient killing of bacteria. The film studied in this work contains gold nanorods (AuNRs) of 32 nm length and 16 nm diameter and gold nanostars (AuNSs) of 50 nm of diameter, in combination with crystal violet dye (CV). The surface plasmon resonance (SPR) of the nanoparticles used in the film was mathematically simulated and characterized to understand difference SPR between the particles. Their effects on plasmonic coupling with the dye, thus the production of reactive oxygen species (ROS) and consequently the activity of the film against bacteria were studied. The films showed great antimicrobial activity against gram negative bacteria (E. coli) in 4 h of light exposure, when modified with AuNSs, it could kill E. coli in 5 orders of magnitudes (5- log) and the one modified with AuNRs could kill with 4 order of magnitudes (4-log). While maintaining partial activity against gram positive bacteria (S. aureus), i.e. being able to kill in 2.5 orders of magnitudes by the film containing AuNSs and 3 orders of magnitudes by those containing AuNRs. The differential response of gram (-) and gram (+) bacteria to the ROS generated by the films, would allow more targeted approach for specific bacterial species, for example, surfaces of bedpans or common contact surfaces (handles, handrails etc.) that are contaminated principally by gram (-) or gram (+) bacteria, respectively.
Details
- Title
- A Study of the Effect of Anisotropic Gold Nanoparticles on Plasmonic Coupling with a Photosensitizer for Antimicrobial Film
- Authors
- Francesco Rossi (Author) - Institute of Materials Research and Engineering, SingaporeEng Huat Khoo (Author) - Institute of High Performance Computing, SingaporeXuai Du Su (Author) - University of the Sunshine Coast - School of Engineering & ScienceNguyen T K Thanh (Author) - University College London, United Kingdom
- Publication details
- ACS Applied Bio Materials, Vol.3(1), pp.315-326
- Publisher
- American Chemical Society
- DOI
- 10.1021/acsabm.9b00838
- ISSN
- 2576-6422
- Organisation Unit
- University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99450977202621
- Output Type
- Journal article
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- Materials Science, Biomaterials
- Nanoscience & Nanotechnology
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