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A Simple Model for Binding and Rupture of Bacterial Cells on Nanopillar Surfaces
Journal article   Peer reviewed

A Simple Model for Binding and Rupture of Bacterial Cells on Nanopillar Surfaces

Gregory S Watson, David W Green, Jolanta A Watson, Zupeng Zhou, Xin Li, Gary S P Cheung and Marty Gellender
Advanced Materials Interfaces, Vol.6(10), 1801646
2019
url
https://doi.org/10.1002/admi.201801646View
Published Version

Abstract

antibacterial bacteria bactericidal models nanostructures
Surfaces based on both chemical and physical mechanisms of attack may yield the next generation of bactericidal and antibacterial surfaces. A simple model is presented based on surface energies explaining the physical action of attack on bacteria (deformation/rupture) by nanopillar surfaces. The analysis is subject to three important constraints which impact on the optimal nanopillar radius, spacing, and length: 1) Nanopillar radius >> the Minimum nanopillar radius which allows for cell wall conformation (so that the surface energy releases when the outer cell layer binds to the nanopillar > work required to bend the layer around the nanopillar). 2) The inter-nanopillar spacing must be << the size of the bacterial cell (so that the cell becomes bound to several nanopillars). 3) The length of the nanopillars must be greater than the distance that the bacteria cell wall would be pulled along the nanopillar shaft.

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Chemistry, Multidisciplinary
Materials Science, Multidisciplinary

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