Journal article
A Review of Major Animal Models Relevant to Contemporary Orthopaedic Repair of the Appendicular Skeleton in Humans (Part 2: osteoporotic bone and imaging studies)
EC Orthopaedics, Vol.4(3), pp.537-552
2016
Abstract
Improved surgical techniques and applied bioengineering have greatly changed orthopaedic practice over the past 50 years. Future changes in orthopaedics are likely to be driven by the ability to understand and alter cell function and apply innovation widely, safely and inexpensively to a much greater proportion of the global population. While much effort is being devoted to the study of skeletal connective tissue and their matrices, there is as much progress to be made in applying and disseminating innovation in a way that is simple and cheap enough to impact the larger proportion of the human population who even in the 21st century are denied interventions based on cost and access. Many animal models have been developed to investigate bone regeneration and repair. Animal models offer the advantage of greater control over experimental design and particularly randomisation between interventions, treatment compliance and end-points that can be pre-determined. The facility to perform elective necropsy substantially increases our understanding of underlying pathology and the healing process. The objective of this series of papers is to review animal models relevant to contemporary orthopaedic surgery of the appendicular skeleton. To help guide readers to relevant data, we have structured our review by major animal species under four broad topics the first two of which were discussed in detail in the first publication. Namely: Healing, bone defects and non-union; and, Healing in the presence of inter-current disease. In this paper, we examine Osteoporotic bone and Imaging studies.
Details
- Title
- A Review of Major Animal Models Relevant to Contemporary Orthopaedic Repair of the Appendicular Skeleton in Humans (Part 2: osteoporotic bone and imaging studies)
- Authors
- Lloyd Reeve-Johnson (Author) - Queensland University of TechnologyM Schuetz (Author) - Queensland University of Technology
- Publication details
- EC Orthopaedics, Vol.4(3), pp.537-552
- Publisher
- ECronicon Open Access
- Date published
- 2016
- Copyright note
- Copyright © All rights reserved by Reeve-Johnson L and Schuetz M. Open Access by ECronicon is licensed under a Creative Commons Attribution 4.0 International License
- Organisation Unit
- Faculty of Science, Health, Education and Engineering; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99451491302621
- Output Type
- Journal article
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