A Researcher’s guide to rodent models of Down syndrome: Recent insights and translational perspectives

Mir Abbas Raza; Andrew Folz; Daniella Victorino; Zhuo Xing; Xu-Qiao Chen; Xinxin Zuo; Leah Borden; Marie-Claude Potier; William Mobley; Mara Dierssen; Masaharu Hiratsuka; Yasuhiro Kazuki; Kristy Welshhans; Michelle Maugham-Macan; Antonella Tramutola; Eitan Okun; Roger Reeves; Randall Roper; Y. Eugene Yu; Yann Hérault; Victor Tybulewicz; Elizabeth Fisher; Aaron Sathyanesan

doi:10.1016/j.xpro.2026.104717

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A Researcher’s guide to rodent models of Down syndrome: Recent insights and translational perspectives

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A Researcher’s guide to rodent models of Down syndrome: Recent insights and translational perspectives

Mir Abbas Raza, Andrew Folz, Daniella Victorino, Zhuo Xing, Xu-Qiao Chen, Xinxin Zuo, Leah Borden, Marie-Claude Potier, William Mobley, Mara Dierssen, …

STAR Protocols, Vol.7(3), pp.1-36

2026

DOI: https://doi.org/10.1016/j.xpro.2026.104717

PMCID: PMC13449384

PMID: 42501327

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Abstract

developmental biology

neuroscience

behavior

NMGN Focused Collection

Rodent models of Down syndrome (DS) have been transformative in identifying basic mechanisms underlying the effects of Trisomy 21 at the molecular, cellular, physiological, and neurobehavioral levels. Each model, with its unique genomic architecture, has advanced our understanding of the complex multisystem etiology of DS. The availability of multiple models necessitates the challenge of selecting appropriate models to address a particular scientific question, experimental design, and translational relevance. This primer guides the reader through the various rodent models of DS and the genomic and phenotypic effects they recapitulate. We also provide recommendations and strategies for using DS rodent models to enable effective and robust forward and reverse translational approaches.

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Title: A Researcher’s guide to rodent models of Down syndrome: Recent insights and translational perspectives
Authors: Mir Abbas Raza - University of Dayton
Andrew Folz - Indiana University
Daniella Victorino - Institut du Cerveau
Zhuo Xing - Roswell Park Comprehensive Cancer Center
Xu-Qiao Chen - University of California San Diego
Xinxin Zuo - University of California San Diego
Leah Borden - Massachusetts Institute of Technology
Marie-Claude Potier - Institut du Cerveau
William Mobley - University of California San Diego
Mara Dierssen - Universitat Pompeu Fabra
Masaharu Hiratsuka - Tottori University
Yasuhiro Kazuki - Tottori University
Kristy Welshhans - University of South Carolina
Michelle Maugham-Macan (Author) - University of the Sunshine Coast
Antonella Tramutola - Sapienza University of Rome
Eitan Okun - Bar-Ilan University
Roger Reeves - Johns Hopkins University School of Medicine
Randall Roper - Indiana University
Y. Eugene Yu - Roswell Park Comprehensive Cancer Center
Yann Hérault - Université de Strasbourg
Victor Tybulewicz - The Francis Crick Institute
Elizabeth Fisher - University College London
Aaron Sathyanesan (Corresponding Author) - University of Dayton
Publication details: STAR Protocols, Vol.7(3), pp.1-36
Publisher: Cell Press
Date published: 2026
DOI: 10.1016/j.xpro.2026.104717
ISSN: 2666-1667
PMID: 42501327; PMC13449384
Organisation Unit: School of Health - Biomedicine; Healthy Ageing Research Cluster; Cancer Research Cluster
Language: English
Record Identifier: 991232801302621
Output Type: Journal article

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