A Preliminary Investigation of the Role of the Phenylalynine:Tyrosine Ratio in Children With Early and Continuously Treated Phenylketonuria: Toward Identification of “Safe” Levels

Rachael Sharman; K A Sullivan; Ross Young; J J McGill

doi:10.1080/87565640903325725

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A Preliminary Investigation of the Role of the Phenylalynine:Tyrosine Ratio in Children With Early and Continuously Treated Phenylketonuria: Toward Identification of “Safe” Levels

Journal article

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A Preliminary Investigation of the Role of the Phenylalynine:Tyrosine Ratio in Children With Early and Continuously Treated Phenylketonuria: Toward Identification of “Safe” Levels

Rachael Sharman, K A Sullivan, Ross Young and J J McGill

Developmental Neuropsychology: an international journal of life-span issues in neuropsychology, Vol.35(1), pp.57-65

2010

DOI: https://doi.org/10.1080/87565640903325725

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Abstract

phenylketonuria

phenylalanine

tyrosine

Children with early and continuously treated phenylketonuria (ECT-PKU) remain at risk of developing executive function (EF) deficits. There is some evidence that a high phenylalanine to tyrosine ratio (phe:tyr) is more strongly associated with impaired EF development than high phenylalanine alone. This study examined EF in a sample of 11 adolescents against concurrent and historical levels of phenylalanine, phe:tyr, and tyrosine. Lifetime measures of phe:tyr were more strongly associated with EF than phenylalanine-only measures. Children with a lifetime phe:tyr less than 6 demonstrated normal EF, whereas children who had a lifetime phe:tyr above 6, on average, demonstrated clinically impaired EF.

Details

Title: A Preliminary Investigation of the Role of the Phenylalynine:Tyrosine Ratio in Children With Early and Continuously Treated Phenylketonuria: Toward Identification of “Safe” Levels
Authors: Rachael Sharman (Author) - Queensland University of Technology
K A Sullivan (Author) - Queensland University of Technology
Ross Young (Author) - Queensland University of Technology
J J McGill (Author) - Royal Children's Hospital
Publication details: Developmental Neuropsychology: an international journal of life-span issues in neuropsychology, Vol.35(1), pp.57-65
Publisher: Psychology Press
Date published: 2010
DOI: 10.1080/87565640903325725
ISSN: 8756-5641
Organisation Unit: School of Social Sciences - Legacy; University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation); School of Health - Psychology; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99449984202621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Psychology; Psychology, Developmental; Psychology, Experimental

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