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Accepted VersionCC BY-NC-ND V4.0, Open Access
Journal article
A DRD2 and ANKK1 haplotype is associated with nicotine dependence
Psychiatry Research, Vol.196(2-3), pp.285-289
2012
PMID: 22382052
Abstract
To test the importance of the dopamine D2 receptor (DRD2) region in nicotine dependence, 150 smokers and 228 controls were genotyped for the DRD2 C957T, -141delC and ANKK1 TaqIA polymorphisms (rs6277, rs1799732 and rs1800497, respectively). The -141delC SNP did not show any association but both the C957T and TaqIA SNPs showed association at the allele, genotype, haplotype and combined genotype levels. The 957C/TaqI A1 haplotype was more than 3.5 times as likely to be associated with nicotine dependence compared with the 957T/TaqI A1 haplotype (P=0.003). Analysis of the combined genotypes of both SNPs revealed that individuals who were homozygous for the 957C-allele (CC) and had either one or two copies of the TaqI A1-allele were 3.3 times as likely to have nicotine dependence compared to all other genotype combinations (P=0.0003) and that these genotypes accounted for approximately 13% of the susceptibility to nicotine addiction in our population. Our findings suggest that the DRD2 C957T polymorphism and the ANKK1 TaqIA polymorphism are key contributors to the genetic susceptibility to nicotine dependence.
Details
- Title
- A DRD2 and ANKK1 haplotype is associated with nicotine dependence
- Authors
- Joanne Voisey (Author) - Queensland University of TechnologyChristopher Dean Swagell (Author) - Queensland University of TechnologyIan Paul Hughes (Author) - Queensland University of TechnologyAngela van Daal (Author) - Queensland University of TechnologyErnest Pascal Noble (Author) - University of California Los AngelesBruce Robert Lawford (Author) - Queensland University of TechnologyRoss Young (Author) - Queensland University of TechnologyCharles Phillip Morris (Author) - Queensland University of Technology
- Publication details
- Psychiatry Research, Vol.196(2-3), pp.285-289
- Publisher
- Elsevier Ireland Ltd.
- Date published
- 2012
- DOI
- 10.1016/j.psychres.2011.09.024
- ISSN
- 1872-7123; 0165-1781
- PMID
- 22382052
- Copyright note
- Copyright © 2012. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99550999402621
- Output Type
- Journal article
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