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A Case-Control Study and Meta-Analysis Reveal BDNF Val66Met Is a Possible Risk Factor for PTSD1.17 MB
Published VersionCC BY V4.0, Open Access
Journal article
A Case-Control Study and Meta-Analysis Reveal BDNF Val66Met Is a Possible Risk Factor for PTSD
Neural Plasticity, Vol.2016, pp.6979435-6979435
2016
PMCID: PMC4928001
PMID: 27413557
Abstract
Posttraumatic stress disorder (PTSD) is a debilitating condition that develops in some people after exposure to a traumatic event. Brain-derived neurotrophic factor (BDNF) is highly expressed in the mammalian brain and is thought to be involved in learning and memory processes. A nonsynonymous polymorphism in the BDNF gene, rs6265 (Val66Met), has been hypothesised to be associated with PTSD. Association studies examining the Val66Met polymorphism and PTSD have been inconclusive, likely due to the variability in type of trauma exposure analysed. Vietnam veterans (n = 257) screened for PTSD and controlled for trauma exposure were genotyped for BDNF Val66Met. The association was not significant so we incorporated our data into a meta-analysis to obtain greater statistical power. A comprehensive search of more than 1237 articles revealed eight additional studies suitable for meta-analysis (n = 3625). A random-effects meta-analysis observed a potential protective factor of the Val/Val genotype. After removing two studies with violation of Hardy-Weinberg equilibrium, findings for the Val/Val genotype reached significance. Subgroup analyses confirmed a trend for this finding. Limitations of some studies that inform this meta-analysis include poorly screened controls and a lack of examination of population stratification. Effectively designed studies should inform this line of research in the future.
Details
- Title
- A Case-Control Study and Meta-Analysis Reveal BDNF Val66Met Is a Possible Risk Factor for PTSD
- Authors
- Dagmar Bruenig (Author) - Institute of Health and Biomedical InnovationJanine Lurie (Author) - Institute of Health and Biomedical InnovationCharles P Morris (Author) - Institute of Health and Biomedical InnovationWendy Harvey (Author) - Greenslopes Private HospitalBruce Lawford (Author) - Institute of Health and Biomedical InnovationRoss Young (Author) - Institute of Health and Biomedical InnovationJoanne Voisey (Author) - Institute of Health and Biomedical Innovation
- Publication details
- Neural Plasticity, Vol.2016, pp.6979435-6979435
- Publisher
- Hindawi Limited
- Date published
- 2016
- DOI
- 10.1155/2016/6979435
- ISSN
- 1687-5443; 2090-5904
- PMID
- 27413557; PMC4928001
- Copyright note
- Copyright © 2016 Dagmar Bruenig et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99551004002621
- Output Type
- Journal article
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