Logo image
Back
4D phase contrast MRI in the preterm infant: Visualisation of patent ductus arteriosus
Journal article   Peer reviewed

4D phase contrast MRI in the preterm infant: Visualisation of patent ductus arteriosus

Kathryn Broadhouse, A N Price, A E Finnemore, D J Cox, A D Edwards, J V Hajnal and A M Groves
Archives of Disease in Childhood, Fetal and Neonatal Edition, Vol.100(2), p.F164
2015
DOI: https://doi.org/10.1136/archdischild-2013-305281
url
https://doi.org/10.1136/archdischild-2013-305281View
Published Version

Abstract

Persistently patent ductus arteriosus (PDA) is correlated with multiple adverse outcomes; however, whether this association is causal or casual remains unclear.1 Echocardiography offers high sensitivity for detection of PDA, but has limited ability to quantify flow within the duct and surrounding vessels. Consequently, the haemodynamic significance can only be inferred.2 Four-dimensional (4D) phase contrast MRI (PCMRI) allows visualisation and quantitative analysis of haemodynamics at almost any anatomical location throughout the cardiac cycle.3 Should adequate spatial resolution be achieved the quantitative nature of PCMRI could provide added value to echocardiographic markers of shunt volume. A free-breathing, non-sedated 4D PCMRI acquired in a 1.1 kg preterm infant born at 24+6 weeks gestation, scanned at 31+1 weeks corrected gestation is shown in figure 1. Ductal shunt volume was 43.5% of left ventricular output determined by 2D PCMRI.2 The morphology of the duct, thoracic vessels and blood flow within are clearly resolved. Particle traces depict blood flow during systole and diastole. Minimal left to right shunting through the duct is apparent during systole. During diastole, chaotic slow flow is visible throughout the ascending aorta and arch; however, particle traces can clearly be seen flowing from the arch into the duct. This illustrates that 4D PCMRI is not only feasible in this fragile population but can provide valuable assessment and insight into the haemodynamic impact of PDA.

Details

Metrics

113 Record Views
4 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types
Domestic collaboration
Web Of Science research areas
Pediatrics

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

Source: InCites

Logo image