3-Year effect of weight loss via severe versus moderate energy restriction on body composition among postmenopausal women with obesity - the TEMPO Diet Trial

Radhika V Seimon; Anthony L Wild-Taylor; Sally McClintock; Claudia Harper; Alice A Gibson; Nathan A Johnson; Hamish A Fernando; Tania P Markovic; Jacqueline R Center; Janet Franklin; Peter Y Liu; Stuart M Grieve; Jim Lagopoulos; Ian D Caterson; Nuala M Byrne; Amanda Sainsbury

doi:10.1016/j.heliyon.2020.e04007

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3-Year effect of weight loss via severe versus moderate energy restriction on body composition among postmenopausal women with obesity - the TEMPO Diet Trial

Journal article

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3-Year effect of weight loss via severe versus moderate energy restriction on body composition among postmenopausal women with obesity - the TEMPO Diet Trial

Radhika V Seimon, Anthony L Wild-Taylor, Sally McClintock, Claudia Harper, Alice A Gibson, Nathan A Johnson, Hamish A Fernando, Tania P Markovic, Jacqueline R Center, Janet Franklin, …

Heliyon, Vol.6(6), pp.1-11

2020

DOI: https://doi.org/10.1016/j.heliyon.2020.e04007

PMCID: PMC7322133

PMID: 32613096

Appears in Thompson Institute Research Collection

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Abstract

Musculoskeletal system

Obesity

Diet

Magnetic resonance imaging

Weight loss

Clinical research

Body composition

Diet-reducing

Other Collaborations

Thompson Institute Special Collection

We have previously shown that a severely energy-restricted diet leads to greater loss of weight, fat, lean mass and bone mineral density (BMD) at 12 months in postmenopausal women with obesity than a moderately energy-restricted diet. We now aim to evaluate whether these effects are sustained longer term (ie, at 36 months). 101 postmenopausal women were randomized to either 12 months of moderate (25 to 35%) energy restriction with a food-based diet (moderate intervention), or 4 months of severe (65 to 75%) energy restriction with a total meal replacement diet followed by moderate energy restriction for 8 months (severe intervention). Body weight and composition were measured at 0, 24 and 36 months. Participants in the severe intervention lost ~1.5 to 1.7 times as much weight, waist circumference, whole-body fat mass and visceral adipose tissue compared to those in the moderate intervention, and were 2.6 times more likely (42% versus 16%) to have lost 10% or more of their initial body weight at 36 months (P < 0.01 for all). However, those in the severe versus moderate intervention lost ~1.4 times as much whole-body lean mass (P < 0.01), albeit this was proportional to total weight lost and there was no greater loss of handgrip strength, and they also lost ~2 times as much total hip BMD between 0 and 36 months (P < 0.05), with this bone loss occurring in the first 12 months. Thus, severe energy restriction is more effective than moderate energy restriction for reducing weight and adiposity in postmenopausal women in the long term (3 years), but attention to BMD loss in the first year is required. Australian New Zealand Clinical Trials Registry Reference Number: 12612000651886, anzctr.org.au. Nutrition; Diet; Musculoskeletal System; Endocrinology; Clinical Research; weight loss; Body composition; diet-reducing; Obesity; Magnetic Resonance Imaging.

Details

Title: 3-Year effect of weight loss via severe versus moderate energy restriction on body composition among postmenopausal women with obesity - the TEMPO Diet Trial
Authors: Radhika V Seimon (Author) - The University of Sydney
Anthony L Wild-Taylor (Author) - The University of Sydney
Sally McClintock (Author) - The University of Sydney
Claudia Harper (Author) - The University of Sydney
Alice A Gibson (Author) - The Boden Collaboration for Obesity, Nutrition, Exercise, and Eating Disorders, Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, Camperdown, New South Wales, Australia
Nathan A Johnson (Author) - The University of Sydney
Hamish A Fernando (Author) - The University of Sydney
Tania P Markovic (Author) - The University of Sydney
Jacqueline R Center (Author) - UNSW Australia
Janet Franklin (Author) - Royal Prince Alfred Hospital
Peter Y Liu (Author) - University of California Los Angeles
Stuart M Grieve (Author) - The University of Sydney
Jim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Ian D Caterson (Author) - The University of Sydney
Nuala M Byrne (Author) - University of Tasmania
Amanda Sainsbury (Author) - The University of Western Australia
Publication details: Heliyon, Vol.6(6), pp.1-11
Publisher: Elsevier Ltd
Date published: 2020
DOI: 10.1016/j.heliyon.2020.e04007
PMID: 32613096; PMC7322133
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99468008402621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Endocrinology & Metabolism

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