10.16 - Bicyclic 6-6 Systems: Three Heteroatoms 1:2

Wendy A Loughlin; Asmaa Boufridi

doi:10.1016/B978-0-12-409547-2.14794-8

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10.16 - Bicyclic 6-6 Systems: Three Heteroatoms 1:2

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10.16 - Bicyclic 6-6 Systems: Three Heteroatoms 1:2

Wendy A Loughlin and Asmaa Boufridi

Comprehensive Heterocyclic Chemistry IV, 4th Edition, Vol.10, pp.638-725

Elsevier Ltd., 4th Edition

2022

DOI: https://doi.org/10.1016/B978-0-12-409547-2.14794-8

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Abstract

Organic chemistry

Organic chemical synthesis

6-6 fused heterocycles

application

pyranopyrazines

pyranopyridazines

pyranopyrimidines

pyridooxazines

pyridopyrazines

pyridopyridazines

pyridopyrimidines

pyridothiazines

reativity

synthesis

thiopyranopyrimidines

The chemistry of 6-6 fused heterocycles containing three heteroatoms arranged 1:2 with no heteroatoms occupying the bridgehead position is reviewed and updated for the period 2006–18. The heterocyclic systems include those with nitrogen, oxygen, sulfur as the heteroatoms and primarily covers pyrido[x,y-z]pyridazine, pyrdimidine, pyrazine rings, along with pyrido-, pyrano-, thiopyrano[x,y-z][1,n]oxazine and thiazine rings. The reactivity, synthetic transformations and methods for their preparation, including fully conjugated and nonconjugated rings, are described. Applications of the heterocycles that have emerged in the decade include, catalytic synthetic approaches, uses in semi-conducting polymers, and significant medicinal chemistry advances (anti-cancer, anti-hypertensive and anti-pain).

Details

Title: 10.16 - Bicyclic 6-6 Systems: Three Heteroatoms 1:2
Authors: Wendy A Loughlin (Author) - Griffith University
Asmaa Boufridi (Author) - Griffith University
Contributors: David StC Black (Editor) - UNSW Australia
Janine Cossy (Editor) - ESPCI Paris
Christian V Stevens (Editor) - Ghent University
Publication details: Comprehensive Heterocyclic Chemistry IV, 4th Edition, Vol.10, pp.638-725
Publisher: Elsevier Ltd.
Edition: 4th Edition
DOI: 10.1016/B978-0-12-409547-2.14794-8
Organisation Unit: School of Health - Biomedicine; Centre for Bioinnovation; School of Science, Technology and Engineering; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99650998102621
Output Type: Encyclopedia entry

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