Editorial
Editorial: The role of pericytes in physiology and pathophysiology
Frontiers in Physiology, Vol.14, pp.1-4
2023
PMCID: PMC10625401
PMID: 37929215
Abstract
In this Research Topic of Frontiers in Physiology, studies outline some of the diverse structural and functional properties of capillary and non-capillary pericytes and pericyte-like cells in health and disease. Capillaries are the site of gas, nutrient, and waste exchange between the blood, cells, and tissues and are located between the arteriole–venule blood supply. The primary role of pericytes is to wrap around regions of the tubular capillary endothelium at intermittent sites, where they contribute to matching metabolic demand to blood flow requirements. This role of pericytes/pericyte-like cells is accompanied by matched structural specialization and diversity in different vascular beds, tissues, and species, as well in development and ageing, as per specific physiological and pathophysiological conditions. In addition to their characterized direct vascular role (Abdelazim et al., Nakisli et al.; Figure 1), including in capillary formation (Kemp et al.), such cells confer non-exclusive and potentially exclusive, selective, and specific functions, encompassing novel roles such as modulating immune cell function, glucose homeostasis, and wound healing (Burganova et al., Preishuber-Pflügl et al.). Notably, a specific molecular marker for pericytes remains elusive (Abdelazim et al., Preishuber-Pflügl et al.).
Details
- Title
- Editorial: The role of pericytes in physiology and pathophysiology
- Authors
- Shaun L. Sandow (Corresponding Author) - University of the Sunshine Coast, Queensland, School of Health - BiomedicineSean M. Wilson (Author) - Loma Linda UniversityM. Dennis Leo (Author) - University of Tennessee Health Science Center
- Publication details
- Frontiers in Physiology, Vol.14, pp.1-4
- Publisher
- Frontiers Research Foundation
- Date published
- 2023
- DOI
- 10.3389/fphys.2023.1306031
- ISSN
- 1664-042X
- PMID
- 37929215; PMC10625401
- Copyright note
- © 2023 Sandow, Wilson and Leo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 99971751102621
- Output Type
- Editorial
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