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Editorial
Early Life Nutrition and the Development of Offspring Metabolic Health
International Journal of Molecular Sciences, Vol.23(15), pp.1-3
2022
PMID: 35897668
Abstract
The developmental origins of health and disease (DOHaD) hypothesis describes the effects of parental perturbations around the periconception, pregnancy, and perinatal window that may lead to changes in offspring development and an increased risk of disease [1]. DOHaD, or simply “developmental programming”, refers to alterations in the physiology, metabolism, and epigenome of an offspring due to poor influences from the offspring’s father or mother [2]. It is well-established that the maternal in utero and early life (perinatal) environments are key to normal organ development and, thus, the disease risk in her offspring [3]. Importantly, more recent research has also determined that a poor paternal perinatal diet has the capacity to affect offspring development and disease risk [4]. The intention of this Special Issue is to explore the diverse recent research, which has showcased the importance of perturbations in maternal nutrition during pregnancy and early life, and the impact of this on the metabolic health of her offspring. Critical to this discussion are sex-specific differences in development and disease risk and the effects of a poor maternal environment on offspring health across the lifespan. Novel studies included in this Special Issue characterised the changes in metabolic health associated with maternal obesity, an elevated omega 6 diet, and elevated fructose diet and cannabis use. Finally, the role of the placental O-GlcNAc transferase in programming insulin sensitivity in offspring was investigated.
Details
- Title
- Early Life Nutrition and the Development of Offspring Metabolic Health
- Authors
- Deanne H. Hryciw (Corresponding Author) - Griffith University
- Publication details
- International Journal of Molecular Sciences, Vol.23(15), pp.1-3
- Publisher
- MDPI AG
- Date published
- 2022
- DOI
- 10.3390/ijms23158096
- ISSN
- 1422-0067; 1661-6596
- PMID
- 35897668
- Copyright note
- © 2022 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 991187230702621
- Output Type
- Editorial
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