Dissertation
Potential involvement of Platelet-Derived microparticles during percutaneous transluminal coronary angioplasty
Doctor of Philosophy, Queensland University of Technology
2004
Abstract
Coronary artery disease is a leading cause of morbidity and mortality in developed countries. Percutaneous transluminal coronary angioplasty (PTCA) is an important treatment option when intervention is required; namely for patients with relatively severe occlusions. However, adverse events including recurrence of angina pectoris and restenosis of the treated artery limit patient prognosis, with subsequent re-vascularisation often necessary. Platelet activation accompanies PTCA, with platelet adhesion and aggregation involved in thrombus formation during restenosis. During platelet activation, highly coagulant platelet-derived microparticles (PMPs) are formed, and it is likely that these PMPs will also be produced during PTCA. While platelet aggregation inhibitors used during PTCA limit platelet aggregation and decrease the incidence of restenosis, they do not prevent PMPs being formed. PMPs are capable of adhesion and aggregation, and adhere to PTCA treated arteries in an animal model. Therefore, in order to understand the phenomenon of restenosis and its improved limitation, it is necessary to investigate PMP formation during PTCA.
Details
- Title
- Potential involvement of Platelet-Derived microparticles during percutaneous transluminal coronary angioplasty
- Authors
- Judy A Craft (Author)
- Awarding institution
- Queensland University of Technology
- Degree awarded
- Doctor of Philosophy
- Language
- English
- Record Identifier
- 99450771502621
- Output Type
- Dissertation
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