Dissertation
Regulation of Macrophage Antioxidant Enzyme Activity and Inflammatory Processes by Omega-3 Polyunsaturated Fatty Acids in Abdominal Aortic Aneurysm
University of the Sunshine Coast, Queensland
Doctor of Philosophy, University of the Sunshine Coast
2019
DOI:
https://doi.org/10.25907/00531
Abstract
Abdominal aortic aneurysm (AAA) is a degenerative vascular disease involving focal dilation of the abdominal aorta (≥3 cm) that can lead to lethal rupture. The condition affects up to 3% of adults over the age of 65 years and no proven pharmacological treatments exist to alter the natural history of progressive expansion over time. In aneurysmal degeneration, immune-inflammatory responses and aberrant redox status initiate molecular events that culminate in destructive remodeling of aortic connective tissue. While the mechanisms underlying these changes remain incompletely understood, preclinical evidence from AAA rodent models suggests treatment strategies targeting vascular inflammation are likely to yield improvements that reduce or attenuate AAA growth. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are well documented to downregulate multiple aspects of the inflammatory process and to quench injury- and infection-induced inflammatory conditions. The potential of these fatty acids to prevent and/or improve adverse outcomes associated with impaired redox balance and disturbed antioxidant status is a new area of investigation that, in conjunction with their anti-inflammatory and pro-resolution properties adds plausibility to their proposed use as an adjunct therapy in AAA. This research thus aimed to evaluate the impact of physiologically appropriate n-3 PUFA supplementation on cellular antioxidant defence in patients diagnosed with small AAA.
Details
- Title
- Regulation of Macrophage Antioxidant Enzyme Activity and Inflammatory Processes by Omega-3 Polyunsaturated Fatty Acids in Abdominal Aortic Aneurysm
- Authors
- Lara T Meital
- Contributors
- Fraser D Russell (Supervisor)
- Awarding institution
- University of the Sunshine Coast
- Degree awarded
- Doctor of Philosophy
- Publisher
- University of the Sunshine Coast, Queensland
- DOI
- 10.25907/00531
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99451109802621
- Output Type
- Dissertation
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