Dissertation
Myokine response to resistance exercise and training in older adults: implications for healthy ageing
University of the Sunshine Coast, Queensland
Doctor of Philosophy, University of the Sunshine Coast, Queensland
2025
DOI:
https://doi.org/10.25907/00923
Abstract
In response to exercise, skeletal muscle produces myokines, allowing crosstalk between the muscle and other organs, including the brain. The emerging role of myokines to mediate cognitive and physical gains seen in exercise suggests that myokines may be valuable biomarkers for monitoring exercise prescription for people with, for example, cancer, diabetes, or neurodegenerative diseases. This is of particular interest in healthy ageing. Muscle quality (MQ) and its decline in older adults, exacerbated by chronic inflammation and elevated cytokine levels, significantly impacts health and functional independence. This deterioration, coupled with unfavourable body compositional changes, can lead to increased frailty, a higher risk of falls, and a greater incidence of chronic diseases due to chronic low-grade systemic inflammation from pro-inflammatory cytokines. Muscle quality, a biomarker of muscle health, may predict myokine production, which exerts anti-inflammatory actions that counteract chronic inflammation. Resistance training (RT), particularly at higher intensities, may enhance muscle quality and reduce inflammation in older adults if adhered to long-term. However, the relationship between muscle quality and myokine expression remains unclear, and research on the acute inflammatory response to resistance exercise in healthy older adults is still inconclusive. This thesis explored inflammatory marker responsiveness to resistance exercise and training and its relationship to muscle quality.
Details
- Title
- Myokine response to resistance exercise and training in older adults: implications for healthy ageing
- Authors
- Isabel King - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
- Contributors
- Mia Schaumberg (Principal Supervisor) - University of the Sunshine Coast, Queensland, Healthy Ageing Research ClusterRobert Buhmann (Co-Supervisor) - University of the Sunshine Coast, Queensland, School of Health - Sports & Exercise ScienceGrace Laura Rose (Co-Supervisor) - University of the Sunshine Coast, Queensland, Cancer Research ClusterNicole B Flemming (Co-Supervisor) - University of the Sunshine Coast, Queensland, School of Health - Biomedicine
- Awarding institution
- University of the Sunshine Coast, Queensland
- Degree awarded
- Doctor of Philosophy
- Publisher
- University of the Sunshine Coast, Queensland
- DOI
- 10.25907/00923
- Grants
- Understanding the acute myokine response to resistance exercise in older adults for longevity and disease prevention., 0980027690, University of the Sunshine Coast (Australia, Sunshine Coast) - UniSC
- Organisation Unit
- School of Health
- Language
- English
- Record Identifier
- 991127503402621
- Output Type
- Dissertation
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