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Muscle Fatigue in Peripheral Arterial Disease: The role of blood flow
Dissertation   Open access

Muscle Fatigue in Peripheral Arterial Disease: The role of blood flow

Brad Stefanovic
University of the Sunshine Coast, Queensland
Doctor of Philosophy, University of the Sunshine Coast
2013
DOI:
https://doi.org/10.25907/00262
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Abstract

Peripheral Arterial Disease walking tolerance intermittent claudication plantar flexion muscle function muscle fatigue exercise blood flow test familiarisation revascularisation supervised exercise therapy
Plantar flexion muscle function and exercise tolerance are reduced in patients with Peripheral Arterial Disease (PAD). Despite PAD being a vascular disease, both haemodynamic and non-haemodynamic factors are postulated to play a role in this decrease in plantar flexion muscle function and exercise tolerance. This thesis aimed to determine the relationship between blood flow and plantar flexion muscle function, specifically, plantar flexion endurance and the rate of fatigue in patients with PAD. This was initially assessed through comparing patients with PAD with control subjects without PAD. As PAD predominately affects older individuals, it was also important to determine the effect of healthy ageing on these factors, separating the effects of age and PAD. Furthermore, this thesis also aimed to determine the effect of revascularisation (treatment aimed at improving haemodynamic factors) and supervised exercise therapy after revascularisation on walking tolerance, plantar flexion muscle function and blood flow.

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