Dissertation
Exercise, Inflammation and Abdominal Aortic Aneurysm
University of the Sunshine Coast, Queensland
Doctor of Philosophy, University of the Sunshine Coast
2018
DOI:
https://doi.org/10.25907/00210
Abstract
Abdominal aortic aneurysm (AAA) is a chronic inflammatory disease characterised by extracellular matrix degeneration and aortic expansion. AAA related deaths account for approximately 2% of all deaths worldwide, and aneurysm repair is the only current treatment option. However, aneurysm repair is only available for patients with a large AAA (≥55mm), and patients with small AAA are left with no current treatment options, despite being at increased risk of mortality due to aortic rupture and other cardiovascular events. In both healthy individuals and clinical populations, exercise has been shown to exert anti-inflammatory effects (Gleeson, Bishop et al. 2011), which may assist in supressing AAA development. Exercise may induce a number of anti-inflammatory actions including the suppression of tumour necrosis factor (TNF-α) (Starkie, Ostrowski et al. 2003) and the matrix degrading enzyme matrix-metalloproteinase (MMP-9) (Kadoglou, Vrabas et al. 2010), and the up-regulation of anti-inflammatory interleukin-6 (IL-6), IL-10 (Steensberg, Fischer et al. 2003, Lira, Rosa et al. 2009) and tumour growth factor-beta (TGF-β1) (Czarkowska-Paczek, Bartlomiejczyk et al. 2006, Perry, Pick et al. 2013). However, responses of these biomarkers to individual bouts of exercise are not known in patients with AAA. The aim of this thesis was to establish whether the circulating inflammatory response to individual bouts of exercise differs in patients with AAA compared to healthy older adults, and if individual bouts of exercise exert anti-inflammatory effects in patients with AAA. As patients with AAA are older and often have low levels of cardiorespiratory fitness, this thesis first examined the effect of exercise intensity and cardiorespiratory fitness in healthy older adults.
Details
- Title
- Exercise, Inflammation and Abdominal Aortic Aneurysm
- Authors
- Mark Windsor
- Contributors
- Christopher D Askew (Supervisor)
- Awarding institution
- University of the Sunshine Coast
- Degree awarded
- Doctor of Philosophy
- Publisher
- University of the Sunshine Coast, Queensland
- DOI
- 10.25907/00210
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health - Sports & Exercise Science; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99450778302621
- Output Type
- Dissertation
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