Dissertation
Evaluation of the anti-inflammatory, anti-oxidant and wound-healing potential of cerumen from the Australian native stingless bee, Tetragonula carbonaria
University of the Sunshine Coast, Queensland
Doctor of Philosophy, University of the Sunshine Coast
2015
DOI:
https://doi.org/10.25907/00591
Abstract
Chronic wounds and excessive scarring are two distinct pathologies that arise when the dynamic and tightly-regulated wound-healing response is disrupted. Both are considered recalcitrant conditions, which are refractory to current therapies and susceptible to high rates of recurrence. Propolis and cerumen, plant-derived products of honeybees and stingless bees, respectively, possess a broad array of biological properties, justifying their use as traditional medicines since antiquity. In particular, they exert anti-oxidant, anti-inflammatory and wound-healing effects; and early evidence suggests that therapeutically-applied propolis may provide benefit in cases of chronic wounds and excessive scarring. The mega-diverse Australian landscape and the species-rich nature of its ecosystems may be abundant sources of natural products for novel wound-healing agents. The Australian native stingless bee, Tetragonula carbonaria, represents a novel source of cerumen; the bioactivities of which are largely unknown. Therefore, the work described in this thesis aimed to determine the anti-oxidant, anti-inflammatory and wound-healing properties of T. carbonaria cerumen, identify its bioactive constituents; and evaluate its potential to provide benefit in cases of pathological wound-healing.
Details
- Title
- Evaluation of the anti-inflammatory, anti-oxidant and wound-healing potential of cerumen from the Australian native stingless bee, Tetragonula carbonaria
- Authors
- Karina D Hamilton
- Contributors
- Fraser D Russell (Supervisor)
- Awarding institution
- University of the Sunshine Coast
- Degree awarded
- Doctor of Philosophy
- Publisher
- University of the Sunshine Coast, Queensland
- DOI
- 10.25907/00591
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Health and Sport Sciences - Legacy; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99449911802621
- Output Type
- Dissertation
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