Dissertation
Dietary inflammatory index and musculoskeletal health: Implications for healthy ageing
University of the Sunshine Coast, Queensland
Doctor of Philosophy, University of the Sunshine Coast, Queensland
2025
DOI:
https://doi.org/10.25907/00931
Abstract
Ageing is associated with numerous chronic diseases, among which musculoskeletal conditions are of high prevalence. This broad category includes osteoporosis (loss of bone mineral content and associated increased fracture risk following a fall), and sarcopenia (loss of lean muscle mass and strength associated with lower physical function), which collectively accounts for nearly 15% of total disease burden in adults over the age of 65 years. Sarcopenia is commonly described as the loss of lean muscle mass and overall strength whereas osteoporosis is defined as the loss of bone mineral density (BMD) or the deterioration of bone tissue. Both conditions result in functional impairment, reduced quality of life through the inability to perform activities of daily living, increased healthcare utilisation, and adverse outcomes such as increased falls and fractures. Chronic inflammation, defined as elevated pro-inflammatory cytokine concentrations directly impacts musculoskeletal health through activating pathways which result in the degradation of muscle proteins and inhibit muscle synthesis, pro-inflammatory cytokines also augment myelopoiesis and osteoclastogenesis, contributing to a decline in BMD. Circulating markers of chronic inflammation are impacted by lifestyle factors and have a direct relationship with the inflammatory potential of the diet. However, research investigating the influence of dietary inflammatory potential on musculoskeletal health in older adults remains scarce.
Details
- Title
- Dietary inflammatory index and musculoskeletal health: Implications for healthy ageing
- Authors
- Corey Linton - University of the Sunshine Coast, Queensland, Healthy Ageing Research Cluster
- Contributors
- Mia Schaumberg (Principal Supervisor) - University of the Sunshine Coast, Queensland, Healthy Ageing Research ClusterHattie Wright (Co-Supervisor) - University of the Sunshine Coast, Queensland, School of Health - Nutrition & DieteticsDana Craven (Co-Supervisor) - University of the Sunshine Coast, Queensland, Australian Centre for Pacific Islands Research
- Awarding institution
- University of the Sunshine Coast, Queensland
- Degree awarded
- Doctor of Philosophy
- Publisher
- University of the Sunshine Coast, Queensland
- DOI
- 10.25907/00931
- Organisation Unit
- School of Health
- Language
- English
- Record Identifier
- 991131905802621
- Output Type
- Dissertation
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