Dissertation
Blood flow during passive leg movement: impact of vascular disease and nitrate supplements
University of the Sunshine Coast, Queensland
Doctor of Philosophy, University of the Sunshine Coast
2019
DOI:
https://doi.org/10.25907/00233
Abstract
Blood flow is regulated by finely tuned vessel dilation and constriction, which is primarily influenced by vasoactive moderators released from the endothelial cells (Hellsten, Nyberg, Jensen, & Mortensen, 2012). Endothelial function is intricately linked to the bioavailability of nitric oxide (NO) (Green, Dawson, Groenewoud, Jones, & Thijssen, 2014), which, in turn, is determined by the balance between NO production (from endothelial nitric oxide synthase and nitrite) and NO consumption (by metabolic reactions and inactivation by reactive oxygen species) (Bredt, 1999b; Lundberg & Weitzberg, 2005; Selemidis, 2008). Nitric oxide has a short half-life, a few milliseconds when in close proximity to other bioreactants (Thomas, Liu, Kantrow, & Lancaster, 2001), making it difficult to measure. Two techniques to assess NO-dependent endothelial function are passive leg movement hyperaemia and flow mediated dilatation (FMD) (Gifford & Richardson, 2017; Thijssen, Black, et al., 2011). Passive leg movement hyperaemia is a novel technique, where the blood flow response appears to be highly dependent on NO bioavailability (Mortensen, Askew, Walker, Nyberg, & Hellsten, 2012; Trinity et al., 2012). In peripheral arterial disease (PAD), conduit vessel blood flow may be limited by atherosclerotic lesions, but there is evidence that endothelial dysfunction also contributes to poor muscle blood flow (Boger & BodeBoger, 1997), and this suggests that NO bioavailability is low. The passive leg movement technique may help characterise blood flow impairment in PAD, providing insight to the underlying pathophysiology.
Details
- Title
- Blood flow during passive leg movement: impact of vascular disease and nitrate supplements
- Authors
- Meegan A Walker
- Contributors
- Christopher D Askew (Supervisor)
- Awarding institution
- University of the Sunshine Coast
- Degree awarded
- Doctor of Philosophy
- Publisher
- University of the Sunshine Coast, Queensland
- DOI
- 10.25907/00233
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health - Sports & Exercise Science; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99450900002621
- Output Type
- Dissertation
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