Abstract
The largest autonomous molecular computing device, MAYA-II, integrates more than 100 deoxyribozyme-based logic gates to play tic-tac-toe interactively against a human opponent. We are now applying elements of MAYA-II for biodetection through the construction of SNAPS (smart nucleic acid pattern sensors). SNAPS detect unique oligonucleotide signatures and display results visually with alphanumerical characters. The devices use a computational approach for pattern identification that provides a concise readout and permits exponential increases in sample numbers.