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Euphorbia peplus–from folklore remedy to clinical treatment for skin cancer
Conference presentation

Euphorbia peplus–from folklore remedy to clinical treatment for skin cancer

Steven Ogbourne
2012 University Research Conference Program Book, p.13
USC Research Conference, 2012 (Sunshine Coast, Australia, 09-Jul-2012–13-Jul-2012)
University of the Sunshine Coast
2012
url
https://www.usc.edu.au/View
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Abstract

Oncology and Carcinogenesis skin cancer Euphorbia peplus
The sap of Euphorbia peplus, commonly known as `petty spurge', `radium weed' or `milkweed', has been used for centuries as a traditional treatment for skin conditions, including warts, corns and non-melanoma skin cancer (NMSC). NMSC is the most common cancer worldwide, with over 2 million patients treated annually in the US, costing US society more than US$1.4 billion for direct treatment alone (The Lewin Group, 2005). In a survey of home remedies for NMSC, administration of E. peplus sap was unanimously considered to be effective; anecdotal evidence that was supported by a clinical trial that resulted in complete cure of 30 out of 48 (62.5%) lesions treated with E.peplus sap. Together, these results supported the identification and commercial development of the active constituent of E. peplus sap. Activity-guided fractionation led to the identification of ingenol-3- angelate as the primary active constituent of the sap and emerged as a promising potential new anti-cancer treatment. This presentation summarises the discovery and development of ingenol-3-angelate through to its approval by the US Food and Drug Administration as a novel therapy for NMSC.

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