Conference presentation
Euphorbia peplus–from folklore remedy to clinical treatment for skin cancer
2012 University Research Conference Program Book, p.13
USC Research Conference, 2012 (Sunshine Coast, Australia, 09-Jul-2012–13-Jul-2012)
University of the Sunshine Coast
2012
Abstract
The sap of Euphorbia peplus, commonly known as `petty spurge', `radium weed' or `milkweed', has been used for centuries as a traditional treatment for skin conditions, including warts, corns and non-melanoma skin cancer (NMSC). NMSC is the most common cancer worldwide, with over 2 million patients treated annually in the US, costing US society more than US$1.4 billion for direct treatment alone (The Lewin Group, 2005). In a survey of home remedies for NMSC, administration of E. peplus sap was unanimously considered to be effective; anecdotal evidence that was supported by a clinical trial that resulted in complete cure of 30 out of 48 (62.5%) lesions treated with E.peplus sap. Together, these results supported the identification and commercial development of the active constituent of E. peplus sap. Activity-guided fractionation led to the identification of ingenol-3- angelate as the primary active constituent of the sap and emerged as a promising potential new anti-cancer treatment. This presentation summarises the discovery and development of ingenol-3-angelate through to its approval by the US Food and Drug Administration as a novel therapy for NMSC.
Details
- Title
- Euphorbia peplus–from folklore remedy to clinical treatment for skin cancer
- Authors
- Steven Ogbourne (Author) - University of the Sunshine Coast - Faculty of Science, Health and Education
- Publication details
- 2012 University Research Conference Program Book, p.13
- Conference details
- USC Research Conference, 2012 (Sunshine Coast, Australia, 09-Jul-2012–13-Jul-2012)
- Publisher
- University of the Sunshine Coast
- Date published
- 2012
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99449264102621
- Output Type
- Conference presentation
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