Conference presentation
Crusted scabies is associated with increased IL-17 secretion by skin T cells
USC Research Conference, 2014 (Sunshine Coast, Australia, 14-Jul-2014–18-Jul-2014)
University of the Sunshine Coast
2014
Abstract
Scabies is an ectoparasitic infestation by the mite Sarcoptes scabiei. Although commonly self-limiting, a fraction of patients develop severely debilitating crusted scabies. The immune mechanisms underlying the development of crusted scabies are unclear, and undertaking longitudinal infection studies in humans is difficult. We utilized a porcine model to compare cellular immune responses in peripheral blood and skin of pigs with different clinical manifestations of scabies (n=12), and in uninfected controls (n=6). Although clinical symptoms were not evident until at least 4 weeks post infestation, the numbers of peripheral IFNγ secreting CD4+ T cells and γδ T cells increased in infected pigs from week 1 post infestation. γδ T cells remained elevated in the blood at week 15 post infestation. At week 15, skin cell infiltrates from pigs with crusted scabies had significantly higher CD8+ T cell, γδ T cell, and IL-17+ cell numbers than those with ordinary scabies. Peripheral IL-17 levels were not increased, suggesting that localised skin IL-17 secreting T cells may play a critical role in the pathogenesis of crusted scabies development. Given the potential of anti-IL-17 immunotherapy demonstrated for other inflammatory skin diseases, this study may provide a novel therapeutic avenue for patients with recurrent crusted scabies.
Details
- Title
- Crusted scabies is associated with increased IL-17 secretion by skin T cells
- Authors
- Xiao Song Liu (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringShelley F Walton (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringHugh C Murray (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringMallory King (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringAndrew Kelly (Author)D C Holt (Author)Bart J Currie (Author)James S McCarthy (Author)Kate E Mounsey (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
- Conference details
- USC Research Conference, 2014 (Sunshine Coast, Australia, 14-Jul-2014–18-Jul-2014)
- Publisher
- University of the Sunshine Coast
- Date published
- 2014
- Copyright note
- Copyright © 2014 The Author.
- Organisation Unit
- School of Health - Biomedicine; GeneCology Research Centre - Legacy; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99448643702621
- Output Type
- Conference presentation
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