ECMO has more profound influence on ciprofloxacin pharmacokinetics in critically ill sheep when compared with healthy sheep

K Shekar; J Roberts; S Diab; K Dunster; C McDonald; S Chemonges; G Simonova; S R Foley; S Wallis; D Platts; Yoke Lin Fung; Maree Smith; J F Fraser

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ECMO has more profound influence on ciprofloxacin pharmacokinetics in critically ill sheep when compared with healthy sheep

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ECMO has more profound influence on ciprofloxacin pharmacokinetics in critically ill sheep when compared with healthy sheep

K Shekar, J Roberts, S Diab, K Dunster, C McDonald, S Chemonges, G Simonova, S R Foley, S Wallis, D Platts, …

Asia-Pacific Chapter of the Extracorporeal Life Support Organisation (APELSO) Conference, 1st (Beijing, China, 11-Oct-2013–13-Oct-2013)

2013

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Abstract

Clinical Sciences

Background / Purpose: Extracoproreal membrane oxygenation (ECMO) is a life saving supportive tool for patients with severe cardiorespiratory failure. However ECMO has a significant impact on pharamcokinetics(PK) of vital drugs that are intended to reverse the pathology which will then result in liberation from ECMO. This mechanistic study aimed to relatively quantify the independent effects of the ECMO device on ciporfloxacin PK.Main conclusion: Critical illness has a major influence on ciprofloxacin PK during ECMO support and the independent effects of ECMO device may not be significant.

Details

Title: ECMO has more profound influence on ciprofloxacin pharmacokinetics in critically ill sheep when compared with healthy sheep
Authors: K Shekar (Author) - University of Queensland
J Roberts (Author) - University of Queensland
S Diab (Author) - University of Queensland
K Dunster (Author) - University of Queensland
C McDonald (Author) - University of Queensland
S Chemonges (Author) - University of Queensland
G Simonova (Author) - University of Queensland
S R Foley (Author) - University of Queensland
S Wallis (Author) - University of Queensland
D Platts (Author) - University of Queensland
Yoke Lin Fung (Author) - University of Queensland
Maree Smith (Author) - University of Queensland
J F Fraser (Author) - University of Queensland
Conference details: Asia-Pacific Chapter of the Extracorporeal Life Support Organisation (APELSO) Conference, 1st (Beijing, China, 11-Oct-2013–13-Oct-2013)
Date published: 2013
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99448898002621
Output Type: Conference poster

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