Conference poster
Autophosphonylating peptides as the scavengers of nerve gas agents
American Chemical Society (ACS) National Meeting, 235th (New Orleans, United States, 06-Apr-2008–10-Apr-2008)
2008
Abstract
Organophosphorus-based inhibitors of the serine esterase acetylcholinesterase, long used as agents for chemical warfare, are extremely toxic. Butyrylcholinesterase (BuChE) is the leading clinical scavenger of nerve agents but low enzymatic turnover rates and a high equivalent weight as a stoichiometric scavenger render maintenance of sufficient BuChE blood levels difficult. We now report development of autocatalytic, low molecular weight peptide-based stoichiometric scavengers. Serine-containing single-peptide-per-bead combinatorial libraries were screened by FACS sarin labeled with Oregon Green as the fluorescent probe. Twenty-four hits were identified and sequenced. Synthesis of soluble peptide, observed reaction with a non-volatile sarin analog and independent synthesis of the products confirmed the hit.
Details
- Title
- Autophosphonylating peptides as the scavengers of nerve gas agents
- Authors
- Z Zhu (Author) - Columbia University, United StatesS-X Deng (Author) - Columbia University, United StatesJoanne Macdonald (Author) - Columbia University, United StatesM Vinogradov (Author) - Columbia University, United StatesD W Landry (Author) - Columbia University, United States
- Conference details
- American Chemical Society (ACS) National Meeting, 235th (New Orleans, United States, 06-Apr-2008–10-Apr-2008)
- Date published
- 2008
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99450270602621
- Output Type
- Conference poster
Metrics
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