Virulence gene profiling of GAS isolates from the Netherlands

David J McMillan; R Geffers; L M Schouls; B J M Vlaminckx; K S Sriprakash; W J Wannet; G S Chhatwal

doi:10.1016/j.ics.2005.11.058

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Virulence gene profiling of GAS isolates from the Netherlands

Conference paper

Peer reviewed

Virulence gene profiling of GAS isolates from the Netherlands

David J McMillan, R Geffers, L M Schouls, B J M Vlaminckx, K S Sriprakash, W J Wannet and G S Chhatwal

International Congress Series, Vol.1289, pp.180-183

Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD), XVIth (Palm Cove, Australia, 25-Sep-2005–29-Sep-2005)

Elsevier BV

2006

DOI: https://doi.org/10.1016/j.ics.2005.11.058

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Abstract

Other Medical and Health Sciences

streptococcus pyogenes

virulence array

emm-type

We have constructed a targeted GAS virulence array containing 228 group A streptococcal genes. Using this array we profiled the virulence gene repertoire of 45 GAS isolates from The Netherlands. Cluster analysis of the array data for these strains successfully grouped strains by emm-type. Statistical analysis of the distribution of genes between emm-types showed that bacteriophage related genes were a significant contributor to the inter-emm-type genetic variation. However we also identified a number of non-phage genes whose distribution varied between emm-types. We hypothesise that these genes may be remnant or uncharacterised phage-related genes.

Details

Title: Virulence gene profiling of GAS isolates from the Netherlands
Authors: David J McMillan (Author) - German Research Centre for Biotechnology, Germany
R Geffers (Author) - German Research Centre for Biotechnology, Germany
L M Schouls (Author) - National Institute of Public Health and the Environment, Netherlands
B J M Vlaminckx (Author) - University Medical Centre, Netherlands
K S Sriprakash (Author) - Queensland Institute of Medical Research
W J Wannet (Author) - National Institute of Public Health and the Environment
G S Chhatwal (Author) - German Research Centre for Biotechnology, Germany
Contributors: K S Sriprakash (Editor)
Publication details: International Congress Series, Vol.1289, pp.180-183
Conference details: Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD), XVIth (Palm Cove, Australia, 25-Sep-2005–29-Sep-2005)
Publisher: Elsevier BV
Date published: 2006
DOI: 10.1016/j.ics.2005.11.058
ISSN: 0531-5131
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450393302621
Output Type: Conference paper

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