Human liver rate-limiting enzymes influence metabolic flux via branch points and inhibitors

Min Zhao; H Qu

doi:10.1186/1471-2164-10-S3-S31

Back

Human liver rate-limiting enzymes influence metabolic flux via branch points and inhibitors

Conference paper

Open access

Peer reviewed

Human liver rate-limiting enzymes influence metabolic flux via branch points and inhibitors

Min Zhao and H Qu

BMC Genomics, Vol.10(Supplement 3), p.S31

International Conference on Bioinformatics (InCoB): Computational Biology, 8th (Singapore, 07-Sep-2009–11-Sep-2009)

BioMed Central Ltd.

2009

DOI: https://doi.org/10.1186/1471-2164-10-S3-S31

Files and links (2)

pdf

PDF - Published Version (Open Access)700.73 kBDownload View

Published VersionPDF - Published Version (Open Access)CCBY_V2.0, Open Access

url

https://doi.org/10.1186/1471-2164-10-S3-S31View

Published Version

Abstract

Biological Sciences

Medical and Health Sciences

Information and Computing Sciences

branch point metabolite

enzyme inhibitor

liver enzyme

liver rate limiting enzyme

unclassified drug

controlled study

enzyme localization

enzyme metabolism

enzyme synthesis

human

metabolic regulation

protein interaction

Background: Rate-limiting enzymes, because of their relatively low velocity, are believed to influence metabolic flux in pathways. To investigate their regulatory role in metabolic networks, we look at the global organization and interactions between rate-limiting enzymes and compounds such as branch point metabolites and enzyme inhibitors in human liver. Results: Based on 96 rate-limiting enzymes and 132 branch point compounds from human liver, we found that rate-limiting enzymes surrounded 76.5% of branch points. In a compound conversion network from human liver, the 128 branch points involved showed a dramatically higher average degree, betweenness centrality and closeness centrality as a whole. Nearly half of the in vivo inhibitors were products of rate-limiting enzymes, and covered 75.34% of the inhibited targets in metabolic inhibitory networks. Conclusion: From global topological organization, rate-limiting enzymes as a whole surround most of the branch points; so they can influence the flux through branch points. Since nearly half of the in vivo enzyme inhibitors are produced by rate-limiting enzymes in human liver, these enzymes can initiate inhibitory regulation and then influence metabolic flux through their natural products. © 2009 Zhao and Qu; licensee BioMed Central Ltd.

Details

Title: Human liver rate-limiting enzymes influence metabolic flux via branch points and inhibitors
Authors: Min Zhao (Author) - Peking University, China
H Qu (Author) - Peking University, China
Publication details: BMC Genomics, Vol.10(Supplement 3), p.S31
Conference details: International Conference on Bioinformatics (InCoB): Computational Biology, 8th (Singapore, 07-Sep-2009–11-Sep-2009)
Publisher: BioMed Central Ltd.
Date published: 2009
DOI: 10.1186/1471-2164-10-S3-S31
ISSN: 1471-2164
Copyright note: Copyright © 2009 Zhao and Qu; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99448802402621
Output Type: Conference paper

Metrics

97 File views/ downloads

810 Record Views