Conference paper
Accurate and quantitative polarization-sensitive OCT by unbiased birefringence estimator with noise-stochastic correction
Proceedings Volume 9697, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX, Vol.9697, 96971I
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine Conference, XX (San Francisco, United States, 15-Feb-2016 - 17-Feb-2016)
S P I E - International Society for Optical Engineering
2016
Abstract
Polarization sensitive optical coherence tomography (PS-OCT) is a functional extension of OCT that contrasts the polarization properties of tissues. It has been applied to ophthalmology, cardiology, etc. Proper quantitative imaging is required for a widespread clinical utility. However, the conventional method of averaging to improve the signal to noise ratio (SNR) and the contrast of the phase retardation (or birefringence) images introduce a noise bias offset from the true value. This bias reduces the effectiveness of birefringence contrast for a quantitative study. Although coherent averaging of Jones matrix tomography has been widely utilized and has improved the image quality, the fundamental limitation of nonlinear dependency of phase retardation and birefringence to the SNR was not overcome. So the birefringence obtained by PS-OCT was still not accurate for a quantitative imaging.
The nonlinear effect of SNR to phase retardation and birefringence measurement was previously formulated in detail for a Jones matrix OCT (JM-OCT) [1]. Based on this, we had developed a maximum a-posteriori (MAP) estimator and quantitative birefringence imaging was demonstrated [2]. However, this first version of estimator had a theoretical shortcoming. It did not take into account the stochastic nature of SNR of OCT signal.
In this paper, we present an improved version of the MAP estimator which takes into account the stochastic property of SNR. This estimator uses a probability distribution function (PDF) of true local retardation, which is proportional to birefringence, under a specific set of measurements of the birefringence and SNR. The PDF was pre-computed by a Monte-Carlo (MC) simulation based on the mathematical model of JM-OCT before the measurement. A comparison between this new MAP estimator, our previous MAP estimator [2], and the standard mean estimator is presented. The comparisons are performed both by numerical simulation and in vivo measurements of anterior and posterior eye segment as well as in skin imaging. The new estimator shows superior performance and also shows clearer image contrast.
Details
- Title
- Accurate and quantitative polarization-sensitive OCT by unbiased birefringence estimator with noise-stochastic correction
- Authors
- Deepa Kasaragod (Author) - University of TsukubaSatoshi Sugiyama (Author) - University of TsukubaYasushi Ikuno (Author) - Osaka University HospitalDavid Alonso-Caneiro (Author) - Queensland University of TechnologyMasahiro Yamanari (Author) - TomeyShinichi Fukuda (Author) - University of TsukubaTetsuro Oshika (Author) - University of TsukubaYoung-Joo Hong (Author) - University of TsukubaEn Li (Author) - University of TsukubaShuichi Makita (Author) - University of TsukubaMasahiro Miura (Author) - Tokyo Medical UniversityYoshiaki Yasuno (Author) - University of Tsukuba
- Contributors
- Joseph A Izatt (Editor) - Duke UniversityJames G Fujimoto (Editor) - Massachusetts Institute of TechnologyValery V Tuchin (Editor) - Saratov State University
- Publication details
- Proceedings Volume 9697, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX, Vol.9697, 96971I
- Conference details
- Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine Conference, XX (San Francisco, United States, 15-Feb-2016 - 17-Feb-2016)
- Publisher
- S P I E - International Society for Optical Engineering
- DOI
- 10.1117/12.2214527
- ISSN
- 2410-9045
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 99973593002621
- Output Type
- Conference paper
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- Optics
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