Using Stem Cells and Synthetic Scaffolds to Model Ethically Sensitive Human Placental Tissue

Georgia R Kafer

doi:10.1007/978-3-030-55924-3_10

Back

Using Stem Cells and Synthetic Scaffolds to Model Ethically Sensitive Human Placental Tissue

Book chapter

Peer reviewed

Using Stem Cells and Synthetic Scaffolds to Model Ethically Sensitive Human Placental Tissue

Georgia R Kafer

Cell-Inspired Materials and Engineering, pp.219-234

Fundamental Biomedical Technologies, Springer

2021

DOI: https://doi.org/10.1007/978-3-030-55924-3_10

Files and links (1)

url

https://doi.org/10.1007/978-3-030-55924-3_10View

Published Version

Abstract

BMP

Placentation

Embryonic stem cell

Organoid

Syncytiotrophoblast

Trophoblast

Placenta

3D culture

Cytotrophoblast

Placentoid

Matrigel

Polydimethylsiloxane

PDMS

Human reproduction, particularly the study of pregnancy, is a challenging field of medical research. Humans can be used in medical research studies with informed consent, but the idea of consent is blurred when we consider the rights of an unborn fetus and the risk that any medical procedure may pose to the developing conceptus. These considerations make obtaining samples of organs associated with an ongoing pregnancy difficult, and force researchers to use suboptimal in vitro or animal research models which limits the depth of investigation. To overcome these issues, there are continuing research efforts aimed at creating innovative ways to model human reproductive tissues. It is hoped that better modeling will enable researchers to delve further into human reproductive biology despite its associated ethical challenges. This chapter will outline the current approaches to study placental development, the potential for using embryonic stem cells to mimic initial stages of placental development and the role that a three-dimensional (3D) culture system may play in such research.

Details

Title: Using Stem Cells and Synthetic Scaffolds to Model Ethically Sensitive Human Placental Tissue
Authors: Georgia R Kafer (Corresponding Author) - Children's Medical Research Institute
Contributors: Dan Ohtan Wang (Editor) - Kyoto University
Daniel Packwood (Editor) - Kyoto University
Publication details: Cell-Inspired Materials and Engineering, pp.219-234
Series: Fundamental Biomedical Technologies
Publisher: Springer
DOI: 10.1007/978-3-030-55924-3_10; 10.1007/978-3-030-55924-3
ISSN: 2626-8655
ISBN: 9783030559243
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy; Centre for Bioinnovation; Australian Centre for Pacific Islands Research
Language: English
Record Identifier: 99554708102621
Output Type: Book chapter

Metrics

58 Record Views