Book chapter
The Structure and Expression of the GABAA Receptor as Deduced by Molecular Genetic Studies
Molecular Biology of Neuroreceptors and Ion Channels, pp.83-89
NATO ASI Series, 32, Springer Verlag
1989
Abstract
It is well established that the inhibitory neurotransmitter γ-aminobutyric acid (GABA) mediates many of its effects by binding to the GABAA receptor, which is present on the majority of mammalian brain neurons (Enna, 1983), resulting in the opening of an integral chloride channel. This receptor has considerable pharmaceutical importance as it contains binding sites for anti-convulsant (barbiturates), anxiogenic (β-carbolines) and convulsant (picrotoxin) drugs (reviewed in Turner and Whittle, 1983; Olsen and Venter, 1986). Although it is known that anxiolytic agents such as benzodiazepines also bind to the GABAA receptor, there exists a population of benzodiazepine-insensitive receptors (Study and Barker, 1981; Unnerstall etal., 1981; de Bias etal., 1988). Our understanding of the molecular structure and function of this receptor complex has been greatly increased by the application of recombinant DNA methodology and the subsequent cloning and expression of cDNA clones that encode its constituent subunits. This chapter will review these advances and describe some recent results arising from the use of the cloned sequences.
Details
- Title
- The Structure and Expression of the GABAA Receptor as Deduced by Molecular Genetic Studies
- Authors
- M G Darlison (Author) - Medical Research Council Centre, United KingdomE A Barnard (Author) - Medical Research Council Centre, United KingdomA N Bateson (Author) - Medical Research Council Centre, United KingdomT A Glencorse (Author) - Medical Research Council Centre, United KingdomRobert J Harvey (Author) - Medical Research Council Centre, United KingdomA A Hicks (Author) - Medical Research Council Centre, United KingdomS P Hunt (Author) - Medical Research Council Centre, United KingdomB J Morris (Author) - Medical Research Council Centre, United KingdomM Vallejo (Author) - Medical Research Council Centre, United KingdomE Vreugdenhil (Author) - Medical Research Council Centre, United KingdomW Wisden (Author) - Medical Research Council Centre, United Kingdom
- Contributors
- A Maelicke (Editor)
- Publication details
- Molecular Biology of Neuroreceptors and Ion Channels, pp.83-89
- Series
- NATO ASI Series; 32
- Publisher
- Springer Verlag
- Date published
- 1989
- DOI
- 10.1007/978-3-642-74155-5_7
- ISBN
- 9783642741579
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99451435102621
- Output Type
- Book chapter
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