Book chapter
The Arabidopsis thaliana Double-Stranded RNA Binding (DRB) Domain Protein Family
Non Coding RNAs in Plants, pp.385-406
RNA Technologies, Springer Berlin Heidelberg
2011
Abstract
Double-stranded RNA (dsRNA) binding domain proteins (dsRBP) are integral players in small non-protein-coding RNA-mediated regulatory pathways in plants, animals and insects. DICER, a RNase III-like class of endonuclease, requires the assistance of a dsRBP to efficiently and accurately process its dsRNA substrate. In the model dicotyledonous plant species Arabidopsis thaliana (Arabidopsis), DICER-LIKE1 (DCL1) requires the coordinated action of dsRNA BINDING DOMAIN1 (DRB1) to process microRNAs (miRNAs) from their precursor molecules of partially self-complementary dsRNA. Small-interfering RNA (siRNA) generation on the contrary, from either endogenous or exogenous transcribed perfectly dsRNA substrates, requires the DCL4/DRB4 partnership. The Arabidopsis genome encodes four DICER-LIKE (DCL) and five double-stranded RNA binding (DRB) proteins. The DCL protein family has been shown to act in both a redundant and hierarchical manner in small RNA (sRNA) biogenesis. The DCL1/DRB1 and DCL4/DRB4 partnerships for miRNA and siRNA production, respectively, suggested that each DCL requires a corresponding DRB protein for its efficient and accurate processing of its associated sRNA class. This chapter covers our current knowledge of the Arabidopsis DRB family members, DRB1 to DRB5, outlining their individual function(s) and DCL association(s) in the parallel sRNA-mediated RNA silencing pathways of Arabidopsis.
Details
- Title
- The Arabidopsis thaliana Double-Stranded RNA Binding (DRB) Domain Protein Family
- Authors
- Andrew Eamens (Author) - University of SydneyShaun J. Curtin (Author) - University of MinnesotaPeter M. Waterhouse (Author) - University of Sydney
- Publication details
- Non Coding RNAs in Plants, pp.385-406
- Series
- RNA Technologies
- Publisher
- Springer Berlin Heidelberg
- Date published
- 2011
- DOI
- 10.1007/978-3-642-19454-2_24; 10.1007/978-3-642-19454-2
- ISBN
- 9783642194542
- Organisation Unit
- School of Health and Behavioural Sciences - Legacy; School of Health - Biomedicine; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99657498802621
- Output Type
- Book chapter
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- Biochemistry & Molecular Biology
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