Book chapter
Ivermectin and moxidectin
Kucers the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, 7th Edition, pp.3351-3369
CRC Press, 7th Edition
2018
Abstract
The macrocyclic lactone class of antibiotics has been a significant addition to human and veterinary medicine since their discovery some 30 years ago. They exhibit a broad spectrum of activity against a range of nematodes and arthropods, are active at low concentration, and have a wide margin of safety. They are classified into two major subfamilies-the avermectins and milbemycins. The differences are based on the presence or the absence of a sugar motif and protonation at C-13. Although the avermectins were the first to be commercialized, the milbemycins were discovered earlier, with milbemycin first identified in 1972 (Takiguchi et al., 1980). This chapter focuses on ivermectin and moxidectin-the two macrocyclic lactones of greatest relevance to human clinical use.
Details
- Title
- Ivermectin and moxidectin
- Authors
- Kate E Mounsey (Author) - University of the Sunshine Coast
- Contributors
- M Lindsay Grayson (Editor)Sara E Cosgrove (Editor)Suzanne Crowe (Editor)William Hope (Editor)James S McCarthy (Editor)John Mills (Editor)Johan W Mouton (Editor)David L Paterson (Editor)
- Publication details
- Kucers the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, 7th Edition, pp.3351-3369
- Publisher
- CRC Press
- Date published
- 2018
- Edition
- 7th Edition
- DOI
- 10.1201/9781315152110
- ISBN
- 9781498747950
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99450624502621
- Output Type
- Book chapter
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