Integrated approaches for marine actinomycete biodiscovery

Larissa Buedenbender; Anthony Richard Carroll; D Ipek Kurtboke

doi:10.2174/9781681086378119050003

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Integrated approaches for marine actinomycete biodiscovery

Book chapter

Peer reviewed

Integrated approaches for marine actinomycete biodiscovery

Larissa Buedenbender, Anthony Richard Carroll and D Ipek Kurtboke

Frontiers in Clinical Drug Research - Anti Infectives, Volume 5, pp.1-40

Bentham Science Publishers Ltd.

2019

DOI: https://doi.org/10.2174/9781681086378119050003

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Abstract

Biochemistry and Cell Biology

Microbiology

actinomycetes

actinobacteria

Actinomycetales

anti-plasmodial activity

Ascidians

chemical diversity

drug discovery

integrated approaches to biodiscovery

marine natural products

microbial metabolome

natural products

Since the discovery of penicillin in 1928, microbial natural products have been exploited as an unexhausted resource for biodiscovery by the pharmaceutical industry. Unlike primary metabolites such as amino acids, carbohydrates and fatty acids that maintain function and utilized for the growth of an organism; secondary metabolites are specific to its producer but not essential for survival. However, the structural complexity of these natural products is closely linked to the ecological role of the producing organism that supports their survival in their niche. Sessile or slowmoving organisms thus rely more heavily on bioactive secondary metabolites, which act as defences, antimicrobials, allelochemicals, signalling molecules, UV protectants or feeding deterrents, thus often form symbiotic associations with microorganisms that produce such metabolites. Technological advancements and the advent of new tools such as nuclear magnetic resonance (NMR) and mass spectrometry (MS) have enhanced our understanding of the bioactivity of these natural products and aided the discovery of numerous biologically active lead structures, drug candidates, and drugs to treat various diseases. This chapter will thus overview the microbiological and chemical techniques currently used to maximize the discovery of new bioactive compounds in particular, the ones from marine actinomycetes that might be further exploited for their potential as novel and potent drug candidates.

Details

Title: Integrated approaches for marine actinomycete biodiscovery
Authors: Larissa Buedenbender (Author) - Griffith University
Anthony Richard Carroll (Author) - Griffith University
D Ipek Kurtboke (Author) - University of the Sunshine Coast
Contributors: Atta-ur-Rahman (Editor)
Publication details: Frontiers in Clinical Drug Research - Anti Infectives, Volume 5, pp.1-40
Publisher: Bentham Science Publishers Ltd.
Date published: 2019
DOI: 10.2174/9781681086378119050003; 10.2174/97816810863781190501
ISSN: 2452-3208; 2452-3208
ISBN: 9781681086385
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99451400802621
Output Type: Book chapter

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