Book chapter
From Bench to Bedside - OncoGelTM, an In Situ Hydrogel for In Vivo Applications
Biodegradable Thermogels, pp.133-144
Biomaterials Science Series, 2, Royal Society of Chemistry (R S C) Publications
2019
Abstract
Localized drug delivery to a tumor site can be an effective treatment regime by increasing local control and decreasing the metastatic potential of the tumor. Utilizing the reverse thermal gelation properties of a class of biocompatible and biodegradable polymers called ReGelâ„¢ copolymers and combining this soft material with a therapeutic agent like Paclitaxel has provided the new drug delivery system OncoGelâ„¢. This chapter summarizes the development of this controlled release formulation, including efficacy, safety and pharmacokinetics studies in animal models and early results from clinical trials. The possibility of using OncoGelâ„¢ as a monotherapy for cancer treatment and in combination with other treatment regimes such as surgery, radiation and chemotherapy is evaluated.
Details
- Title
- From Bench to Bedside - OncoGelTM, an In Situ Hydrogel for In Vivo Applications
- Authors
- Ankshita Prasad (Author) - Institute of Materials Research and EngineeringDavid James Young (Author) - University of the Sunshine CoastXian Jun Loh (Author) - Institute of Materials Research and Engineering
- Contributors
- Xian Jun Loh (Editor)David James Young (Editor)
- Publication details
- Biodegradable Thermogels, pp.133-144
- Series
- Biomaterials Science Series; 2
- Publisher
- Royal Society of Chemistry (R S C) Publications
- Date published
- 2019
- DOI
- 10.1039/9781788012676-00133; 10.1039/9781788012676
- Organisation Unit
- University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99450768402621
- Output Type
- Book chapter
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