Fibrinogen, Coagulation, and Ageing

Rebecca Donkin; Yoke Lin Fung; Indu Singh

doi:10.1007/978-3-031-21410-3_12

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Fibrinogen, Coagulation, and Ageing

Rebecca Donkin, Yoke Lin Fung and Indu Singh

Biochemistry and Cell Biology of Ageing: Part III Biomedical Science, pp.313-342

Subcellular Biochemistry, 102, Springer

2023

DOI: https://doi.org/10.1007/978-3-031-21410-3_12

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Abstract

Fibrinogen

coagulation

aging

older age

platelets

anticoagulation

laboratory monitoring

point-of-care testing

reference intervals

UniSC Diversity Area - Life Stages

The World Health Organization estimates that the world’s population over 60 years of age will nearly double in the next 30 years. This change imposes increasing demands on health and social services with increased disease burden in older people, hereafter defined as people aged 60 years or more. An older population will have a greater incidence of cardiovascular disease partly due to higher levels of blood fibrinogen, increased levels of some coagulation factors, and increased platelet activity. These factors lead to a hypercoagulable state which can alter haemostasis, causing an imbalance in appropriate coagulation, which plays a crucial role in the development of cardiovascular diseases. These changes in haemostasis are not only affected by age but also by gender and the effects of hormones, or lack thereof in menopause for older females, ethnicity, other comorbidities, medication interactions, and overall health as we age. Another confounding factor is how we measure fibrinogen and coagulation through laboratory and point-of-care testing and how our decision-making on disease and treatment (including anticoagulation) is managed. It is known throughout life that in normal healthy individuals the levels of fibrinogen and coagulation factors change, however, reference intervals to guide diagnosis and management are based on only two life stages, paediatric, and adult ranges. There are no specific diagnostic guidelines based on reference intervals for an older population. How ageing relates to alterations in haemostasis and the impact of the disease will be discussed in this chapter. Along with the effect of anticoagulation, laboratory testing of fibrinogen and coagulation, future directions, and implications will be presented.

Details

Title: Fibrinogen, Coagulation, and Ageing
Authors: Rebecca Donkin (Corresponding Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
Yoke Lin Fung (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
Indu Singh (Author) - Griffith University
Contributors: J Robin Harris (Editor) - Johannes Gutenberg University Mainz
Victor I Korolchuk (Editor) - Newcastle University
Publication details: Biochemistry and Cell Biology of Ageing: Part III Biomedical Science, pp.313-342
Series: Subcellular Biochemistry; 102
Publisher: Springer
Date published: 2023
DOI: 10.1007/978-3-031-21410-3_12; 10.1007/978-3-031-21410-3
ISSN: 2542-8810
ISBN: 9783031214103
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health - Biomedicine; School of Health and Behavioural Sciences - Legacy; Cancer Research Cluster
Language: English
Record Identifier: 99698098902621
Output Type: Book chapter

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