Book chapter
Dietary AGEs in the Development and Progression of Chronic Kidney Disease
Dietary AGEs and their Role in Health and Disease, pp.213-224
CRC Press
2018
Abstract
This chapter reviews the evidence for excess consumption of Advanced glycation end products (AGEs) contributing to the development and progression of Chronic kidney disease (CKD). Kidney damage is determined by markers such as proteinuria and abnormalities in urine and blood chemistry, while decreased kidney function is determined by a decline in estimated glomerular filtration rate. End-stage renal disease (ESRD) describes patients who are at Stage 5 of CKD and are being treated with dialysis or kidney transplantation. A number of clinical studies reported that circulating AGEs accumulate with a progressive decline in renal function, even in the absence of diabetes, and with markers of inflammation and oxidative stress in uremic patients. Dietary modulation of AGEs may be a simple, cost-effective, and complementary treatment option for CKD. Indeed, a low-AGE diet, which lowered serum and kidney AGE levels, protected against diabetic nephropathy in spontaneous mouse models of both type 1 and type 2 diabetes.
Details
- Title
- Dietary AGEs in the Development and Progression of Chronic Kidney Disease
- Authors
- Amelia K. Fotheringham (Author) - University of QueenslandLinda Gallo (Author) - University of QueenslandJosephine M Forbes (Author) - University of Queensland
- Contributors
- Jaime Uribarri (Contributor) - Icahn School of Medicine at Mount Sinai
- Publication details
- Dietary AGEs and their Role in Health and Disease, pp.213-224
- Publisher
- CRC Press
- DOI
- 10.1201/9781315120041-20; 10.1201/9781315120041
- ISBN
- 9781315120041
- Organisation Unit
- School of Health and Behavioural Sciences - Legacy; University of the Sunshine Coast, Queensland; School of Health - Biomedicine
- Language
- English
- Record Identifier
- 99620506602621
- Output Type
- Book chapter
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